دورية أكاديمية
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
| العنوان: | Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint |
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| المؤلفون: | Wischhusen, Jörg, Melero, Ignacio, Fridman, Wolf, Herman |
| المساهمون: | University Hospital of Würzburg, Center for Applied Medical Research Plamplona (CIMA), Universidad de Navarra Pamplona (UNAV), Clínica Universidad de Navarra Pamplona, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité) |
| المصدر: | ISSN: 1664-3224. |
| بيانات النشر: | HAL CCSD Frontiers |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | anorexia, autoimmunity, cancer, growth/differentiation factor-15 (GDF-15), immune exclusion, immunotherapy, macrophage inhibitory cytokine-1 (MIC-1), pregnancy, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity |
| الوصف: | International audience ; Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a divergent member of the transforming growth factor β superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF-15 is abundant in placenta. Elsewhere, GDF-15 is often induced under stress conditions, seemingly to maintain cell and tissue homeostasis; however, a moderate increase in GDF-15 blood levels is observed with age. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 has thus been widely explored as a biomarker for disease prognosis. Mechanistically, induction of anorexia via the brainstem-restricted GDF-15 receptor GFRAL (glial cell-derived neurotrophic factor [GDNF] family receptor α-like) is well-documented. GDF-15 and GFRAL have thus become attractive targets for metabolic intervention. Still, several GDF-15 mediated effects (including its physiological role in pregnancy) are difficult to explain via the described pathway. Hence, there is a clear need to better understand non-metabolic effects of GDF-15. With particular emphasis on its immunomodulatory potential this review discusses the roles of GDF-15 in pregnancy and in pathological conditions including myocardial infarction, autoimmune disease, and specifically cancer. Importantly, the strong predictive value of GDF-15 as biomarker may plausibly be linked to its immune-regulatory function. The described associations and mechanistic data support the hypothesis that GDF-15 acts as immune checkpoint and is thus an emerging target for cancer immunotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32508832; hal-02878344; https://hal.sorbonne-universite.fr/hal-02878344Test; https://hal.sorbonne-universite.fr/hal-02878344/documentTest; https://hal.sorbonne-universite.fr/hal-02878344/file/fimmu-11-00951.pdfTest; PUBMED: 32508832; PUBMEDCENTRAL: PMC7248355 |
| DOI: | 10.3389/fimmu.2020.00951 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2020.00951Test https://hal.sorbonne-universite.fr/hal-02878344Test https://hal.sorbonne-universite.fr/hal-02878344/documentTest https://hal.sorbonne-universite.fr/hal-02878344/file/fimmu-11-00951.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E7726E18 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2020.00951 |
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