دورية أكاديمية
Oncologic Trogocytosis of an Original Stromal Cells Induces Chemoresistance of Ovarian Tumours
| العنوان: | Oncologic Trogocytosis of an Original Stromal Cells Induces Chemoresistance of Ovarian Tumours |
|---|---|
| المؤلفون: | Rafii, Arash, Mirshahi, Pejman, Poupot, Mary, Faussat, Anne-Marie, Simon, Anne, Ducros, Elodie, Mery, Eliane, Couderc, Bettina, Lis, Raphael, Capdet, Jérôme, Bergalet, Julie, Querleu, Denis, Dagonnet, Francoise, Fournié, Jean-Jacques, Marie, Jean-Pierre, Pujade-Lauraine, Eric, Favre, Gilles, Soria, Jeanine, Mirshahi, Massoud |
| المساهمون: | Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IFR 31 Louis Bugnard (IFR 31), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Physiopathologie de Toulouse-Purpan (INSERM U563 - CNRS UMR1037), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut Claudius Regaud-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de lutte contre le cancer (CLCC)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences Pharmaceutiques, Université de Toulouse (UT)-Université de Toulouse (UT) |
| المصدر: | ISSN: 1932-6203. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2008 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology |
| الوصف: | International audience ; BACKGROUND:The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal homeostasis; we determined their role in the acquisition of chemoresistance of ovarian tumours.METHODOLOGY/PRINCIPAL FINDINGS:We isolated an original type of stromal cells, referred to as "Hospicells" from ascitis of patients with ovarian carcinosis using limiting dilution. We studied their ability to confer chemoresistance through heterocellular interactions. These stromal cells displayed a new phenotype with positive immunostaining for CD9, CD10, CD29, CD146, CD166 and Multi drug resistance protein. They preferentially interacted with epithelial ovarian cancer cells. This interaction induced chemoresistance to platin and taxans with the implication of multi-drug resistance proteins. This contact enabled EOC cells to capture patches of the Hospicells membrane through oncologic trogocytosis, therefore acquiring their functional P-gp proteins and thus developing chemoresistance. Presence of Hospicells on ovarian cancer tissue micro-array from patients with neo-adjuvant chemotherapy was also significantly associated to chemoresistance.CONCLUSIONS/SIGNIFICANCE:This is the first report of trogocytosis occurring between a cancer cell and an original type of stromal cell. This interaction induced autonomous acquisition of chemoresistance. The presence of stromal cells within patient's tumour might be predictive of chemoresistance. The specific interaction between cancer cells and stromal cells might be targeted during chemotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19079610; inserm-02472253; https://inserm.hal.science/inserm-02472253Test; https://inserm.hal.science/inserm-02472253/documentTest; https://inserm.hal.science/inserm-02472253/file/journal.pone.0003894.PDFTest; PUBMED: 19079610; PUBMEDCENTRAL: PMC2597737 |
| DOI: | 10.1371/journal.pone.0003894 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0003894Test https://inserm.hal.science/inserm-02472253Test https://inserm.hal.science/inserm-02472253/documentTest https://inserm.hal.science/inserm-02472253/file/journal.pone.0003894.PDFTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E7489564 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0003894 |
|---|