دورية أكاديمية
Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model
| العنوان: | Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model |
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| المؤلفون: | Mariza de Andrade, Sebastian M. Armasu, Bryan M. McCauley, Tanya M. Petterson, John A. Heit |
| المصدر: | International Journal of Environmental Research and Public Health, Vol 14, Iss 10, p 1228 (2017) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | genome-wide association study, genetic variation, pregnancy complications, risk factors, venous thromboembolism, Medicine |
| الوصف: | Background: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths. Methods: We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model adjusted for covariates to identify genetic variants associated with the time-to-event of VTE related to pre- or postpartum during the childbearing age of 18–45 years using a case-only design in a cohort of women with VTE. Women with a VTE event after 45 years of age were censored and contributed only follow-up time. Results: We identified two intragenic single nucleotide polymorphisms (SNPs) at genome-wide significance in the PURB gene located on chromosome 7, and two additional intragenic SNPs, one in the LINGO2 gene on chromosome 9 and one in RDXP2 on chromosome X. Conclusions: We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1660-4601 |
| العلاقة: | https://www.mdpi.com/1660-4601/14/10/1228Test; https://doaj.org/toc/1660-4601Test; https://doaj.org/article/a5391af571134099883289556e963a4aTest |
| DOI: | 10.3390/ijerph14101228 |
| الإتاحة: | https://doi.org/10.3390/ijerph14101228Test https://doaj.org/article/a5391af571134099883289556e963a4aTest |
| رقم الانضمام: | edsbas.E700A0A0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16604601 |
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| DOI: | 10.3390/ijerph14101228 |