دورية أكاديمية
Time Spent in Hypoglycemia According to Age and Time of Day:Observations During Closed-Loop Insulin Delivery
| العنوان: | Time Spent in Hypoglycemia According to Age and Time of Day:Observations During Closed-Loop Insulin Delivery |
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| المؤلفون: | Alwan, Heba, Ware, Julia, Boughton, Charlotte K, Wilinska, Malgorzata E, Allen, Janet M, Lakshman, Rama, Nwokolo, Munachiso, Hartnell, Sara, Bally, Lia, de Beaufort, Carine, Besser, Rachel E J, Campbell, Fiona M, Davis, Nikki, Denvir, Louise, Evans, Mark L, Fröhlich-Reiterer, Elke, Ghatak, Atrayee, Hofer, Sabine E, Kapellen, Thomas M, Leelarathna, Lalantha, Mader, Julia K, Narendran, Parth, Rami-Mehrar, Birgit, Tauschmann, Martin, Thabit, Hood, Thankamony, Ajay, Hovorka, Roman |
| المصدر: | Alwan , H , Ware , J , Boughton , C K , Wilinska , M E , Allen , J M , Lakshman , R , Nwokolo , M , Hartnell , S , Bally , L , de Beaufort , C , Besser , R E J , Campbell , F M , Davis , N , Denvir , L , Evans , M L , Fröhlich-Reiterer , E , Ghatak , A , Hofer , S E , Kapellen , T M , Leelarathna , L , Mader , J K , Narendran , P , .... |
| سنة النشر: | 2023 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | Adolescent, Aged, Child, Preschool, Humans, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 1/drug therapy, Hypoglycemia/chemically induced, Hypoglycemic Agents/therapeutic use, Insulin/adverse effects, Insulin Infusion Systems, Insulin, Regular, Human/therapeutic use, Retrospective Studies, Treatment Outcome, Young Adult, Adult, Middle Aged |
| الوصف: | Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4-5.0]) and very young children (4.0% [3.4-5.2]), followed by adults (2.7% [1.7-4.0]), and older adults (1.8% [1.2-2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight-05:59) was lower than during daytime (06:00-23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.manchester.ac.uk/en/publications/48483577-3d0e-4112-a4c4-fa32e633a002Test |
| DOI: | 10.1089/dia.2023.0061 |
| الإتاحة: | https://doi.org/10.1089/dia.2023.0061Test https://research.manchester.ac.uk/en/publications/48483577-3d0e-4112-a4c4-fa32e633a002Test http://www.scopus.com/inward/record.url?scp=85164238820&partnerID=8YFLogxKTest https://www.mendeley.com/catalogue/91387a7c-36d6-380f-9b7f-c4323448150bTest/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E6E3CF65 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/dia.2023.0061 |
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