دورية أكاديمية
A Comprehensive Overview of the Past, Current, and Future Randomized Controlled Trials in Hepatic Encephalopathy
| العنوان: | A Comprehensive Overview of the Past, Current, and Future Randomized Controlled Trials in Hepatic Encephalopathy |
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| المؤلفون: | Ovidiu-Dumitru Ilie, Raluca Duta, Ilinca-Bianca Nita, Irina Dobrin, Irina-Luciana Gurzu, Irina Girleanu, Laura Huiban, Cristina Muzica, Alin Ciobica, Roxana Popescu, Petru Cianga, Carol Stanciu, Diana Cimpoesu, Anca Trifan |
| المصدر: | Medicina, Vol 59, Iss 12, p 2143 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | hepatic encephalopathy, fecal microbiota transplantation, probiotics, prebiotics, synbiotics, randomized controlled trials, Medicine (General), R5-920 |
| الوصف: | Background: Hepatic encephalopathy (HE) caused by cirrhosis has severe consequences on an individual’s lifespan, leading to long-term liver complications and potentially life-threatening outcomes. Despite recent interest in this condition, the effectiveness of secondary prophylaxis involving rixafimin, lactulose, or L-ornithine L-aspartate (LOLA) may be hindered by the unique microbial profiles each patient possesses. Methods: Thus, in this manuscript, we aimed to search, identify, and gather all randomized controlled trials (RCTs) published between 2000–2023 (November) in four major academic databases such as PubMed, ISI Web of Science, Scopus, and ScienceDirect by using a controlled terminology and web strings that reunite six main keywords. We complementarily retrieved data on the ongoing RCTs. Results: Regardless of the relatively high number of results displayed ( n = 75), 46.66% ( n = 35) were initially deemed eligible after the first evaluation phase after removing duplicates, n = 40 (53.34%). At the second assessment stage, we eliminated 11.42% ( n = 4) studies, of which n = 22 finally met the eligibility criteria to be included in the main body of the manuscript. In terms of RCTs, otherwise found in distinct stages of development, n = 3 target FMT and n = 1 probiotics. Conclusions: Although we benefit from the necessary information and technology to design novel strategies for microbiota, only probiotics and synbiotics have been extensively studied in the last decade compared to FMT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| العلاقة: | https://www.mdpi.com/1648-9144/59/12/2143Test; https://doaj.org/toc/1010-660XTest; https://doaj.org/toc/1648-9144Test; https://doaj.org/article/0484a61a90c14a198798c987bcd1abe8Test |
| DOI: | 10.3390/medicina59122143 |
| الإتاحة: | https://doi.org/10.3390/medicina59122143Test https://doaj.org/article/0484a61a90c14a198798c987bcd1abe8Test |
| رقم الانضمام: | edsbas.E6C2B1B6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16489144 1010660X |
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| DOI: | 10.3390/medicina59122143 |