دورية أكاديمية
Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
| العنوان: | Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts |
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| المؤلفون: | Rothwell, JA, Bešević, J, Dimou, N, Breeur, M, Murphy, N, Jenab, M, Wedekind, R, Viallon, V, Ferrari, P, Achaintre, D, Gicquiau, A, Rinaldi, S, Scalbert, A, Huybrechts, I, Prehn, C, Adamski, J, Cross, AJ, Keun, H, Chadeau-Hyam, M, Boutron-Ruault, M-C, Overvad, K, Dahm, CC, Nøst, TH, Sandanger, TM, Skeie, G, Zamora-Ros, R, Tsilidis, KK, Eichelmann, F, Schulze, MB, Van Guelpen, B, Vidman, L, Sánchez, M-J, Amiano, P, Ardanaz, E, Smith-Byrne, K, Travis, R, Katzke, V, Kaaks, R, Derksen, JWG, Colorado-Yohar, S, Tumino, R, Bueno-de-Mesquita, B, Vineis, P, Palli, D, Pasanisi, F, Eriksen, AK, Tjønneland, A, Severi, G, Gunter, MJ |
| المصدر: | 13 ; 1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2023 |
| المجموعة: | Imperial College London: Spiral |
| جغرافية الموضوع: | England |
| الوصف: | BACKGROUND: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. METHODS: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. RESULTS: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87-0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75-0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89-1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded. CONCLUSIONS: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1741-7015 |
| العلاقة: | BMC Medicine; http://hdl.handle.net/10044/1/102784Test |
| DOI: | 10.1186/s12916-023-02739-4 |
| الإتاحة: | https://doi.org/10.1186/s12916-023-02739-4Test http://hdl.handle.net/10044/1/102784Test |
| حقوق: | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. The Creative Commons Public Domain Dedication waiver (http://creativecoTest mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.E60AD8D4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17417015 |
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| DOI: | 10.1186/s12916-023-02739-4 |