دورية أكاديمية
Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve
| العنوان: | Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve |
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| المؤلفون: | Kleineidam, Luca, Wolfsgruber, Steffen, Weyrauch, Anne-Sophie, Zulka, Linn E., Forstmeier, Simon, Roeske, Sandra, Bussche, Hendrik van den, Kaduszkiewicz, Hanna, Wiese, Birgitt, Weyerer, Siegfried, Werle, Jochen, Fuchs, Angela, Pentzek, Michael, Brettschneider, Christian, König, Hans-Helmut, Weeg, Dagmar, Bickel, Horst, Luppa, Melanie, Rodriguez, Francisca S., Freiesleben, Silka Dawn, Erdogan, Selin, Unterfeld, Chantal, Peters, Oliver, Spruth, Eike J., Altenstein, Slawek, Lohse, Andrea, Priller, Josef, Fliessbach, Klaus, Kobeleva, Xenia, Schneider, Anja, Bartels, Claudia, Schott, Björn H., Wiltfang, Jens, Maier, Franziska, Glanz, Wenzel, Incesoy, Enise I., Butryn, Michaela, Düzel, Emrah, Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Rauchmann, Boris-Stephan, Perneczky, Robert, Kilimann, Ingo, Görß, Doreen, Teipel, Stefan, Laske, Christoph, Munk, Matthias H. J., Spottke, Annika, Roy, Nina, Brosseron, Frederic, Heneka, Michael T., Ramirez, Alfredo, Yakupov, Renat, Scherer, Martin, Maier, Wolfgang, Jessen, Frank, Riedel-Heller, Steffi G., Wagner, Michael |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2024 |
| المجموعة: | TU Darmstadt: tuprints |
| الوصف: | Introduction: Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), brain reserve (BR), or cognitive reserve (CR) or a combination of them. Methods: We systematically derived hypotheses for these resilience concepts and tested them in the population-based AgeCoDe cohort and memory clinic-based AD high-risk DELCODE study. The OCR score (OCRS) was measured using job activities based on the O*NET occupational classification system. Four sets of analyses were conducted: (1) the interaction of OCR and APOE-ε4 with regard to cognitive decline (N = 2,369, AgeCoDe), (2) association with differentially shaped retrospective trajectories before the onset of dementia of the Alzheimer's type (DAT; N = 474, AgeCoDe), (3) cross-sectional interaction of the OCR and cerebrospinal fluid (CSF) AD biomarkers and brain structural measures regarding memory function (N = 873, DELCODE), and (4) cross-sectional and longitudinal association of OCR with CSF AD biomarkers and brain structural measures (N = 873, DELCODE). Results: Regarding (1), higher OCRS was associated with a reduced association of APOE-ε4 with cognitive decline (mean follow-up = 6.03 years), consistent with CR and BR. Regarding (2), high OCRS was associated with a later onset but subsequently stronger cognitive decline in individuals converting to DAT, consistent with CR. Regarding (3), higher OCRS was associated with a weaker association of the CSF Aβ42/40 ratio and hippocampal volume with memory function, consistent with CR. Regarding (4), OCR was not associated with the levels or changes in CSF AD biomarkers (mean follow-up = 2.61 years). We found a cross-sectional, age-independent association of OCRS with some MRI markers, but no association with 1-year-change. OCR was not associated with the intracranial volume. These results ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://tuprints.ulb.tu-darmstadt.de/23103/8/fpsyg-13-957308.pdfTest; https://tuprints.ulb.tu-darmstadt.de/23103/11/Data_Sheet_1.pdfTest; Kleineidam, Luca; Wolfsgruber, Steffen; Weyrauch, Anne-Sophie; Zulka, Linn E.; Forstmeier, Simon; Roeske, Sandra; Bussche, Hendrik van den; Kaduszkiewicz, Hanna; Wiese, Birgitt; Weyerer, Siegfried; Werle, Jochen; Fuchs, Angela; Pentzek, Michael; Brettschneider, Christian; König, Hans-Helmut; Weeg, Dagmar; Bickel, Horst; Luppa, Melanie; Rodriguez, Francisca S.; Freiesleben, Silka Dawn; Erdogan, Selin; Unterfeld, Chantal; Peters, Oliver; Spruth, Eike J.; Altenstein, Slawek; Lohse, Andrea; Priller, Josef; Fliessbach, Klaus; Kobeleva, Xenia; Schneider, Anja; Bartels, Claudia; Schott, Björn H.; Wiltfang, Jens; Maier, Franziska; Glanz, Wenzel; Incesoy, Enise I.; Butryn, Michaela; Düzel, Emrah; Buerger, Katharina; Janowitz, Daniel; Ewers, Michael; Rauchmann, Boris-Stephan; Perneczky, Robert; Kilimann, Ingo; Görß, Doreen; Teipel, Stefan; Laske, Christoph; Munk, Matthias H. J.; Spottke, Annika; Roy, Nina; Brosseron, Frederic; Heneka, Michael T.; Ramirez, Alfredo; Yakupov, Renat; Scherer, Martin; Maier, Wolfgang; Jessen, Frank; Riedel-Heller, Steffi G.; Wagner, Michael (2024)Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve. In: Frontiers in Psychology, 2022, 13 doi:10.26083/tuprints-00023103 Article, Secondary publication, Publisher's Version |
| DOI: | 10.26083/tuprints-00023103 |
| الإتاحة: | https://doi.org/10.26083/tuprints-00023103Test http://tuprints.ulb.tu-darmstadt.de/23103Test/ https://tuprints.ulb.tu-darmstadt.de/23103/8/fpsyg-13-957308.pdfTest https://tuprints.ulb.tu-darmstadt.de/23103/11/Data_Sheet_1.pdfTest |
| حقوق: | CC BY 4.0 International - Creative Commons, Attribution ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E5F265E9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.26083/tuprints-00023103 |
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