دورية أكاديمية
Factors associated with anxiety disorder comorbidity
| العنوان: | Factors associated with anxiety disorder comorbidity |
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| المؤلفون: | Davies, Molly R, Glen, Kiran, Mundy, Jessica, Ter Kuile, Abigail R, Adey, Brett N, Armour, Chérie, Assary, Elham, Coleman, Jonathan R I, Goldsmith, Kimberley A, Hirsch, Colette R, Hotopf, Matthew, Hübel, Christopher, Jones, Ian R, Kalsi, Gursharan, Krebs, Georgina, McIntosh, Andrew M, Morneau-Vaillancourt, Geneviève, Peel, Alicia J, Purves, Kirstin L, Lee, Sang Hyuck, Skelton, Megan, Smith, Daniel J, Veale, David, Walters, James T R, Young, Katherine S, Zvrskovec, Johan, Breen, Gerome, Eley, Thalia C |
| المصدر: | Davies , M R , Glen , K , Mundy , J , Ter Kuile , A R , Adey , B N , Armour , C , Assary , E , Coleman , J R I , Goldsmith , K A , Hirsch , C R , Hotopf , M , Hübel , C , Jones , I R , Kalsi , G , Krebs , G , McIntosh , A M , Morneau-Vaillancourt , G , Peel , A J , Purves , K L , Lee , S H , Skelton , M , Smith , .... |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Affective disorders, Anxiety disorders, Comorbidity, Depressive disorders, Polygenic risk score |
| الوصف: | BACKGROUND: Anxiety and depressive disorders often co-occur and the order of their emergence may be associated with different clinical outcomes. However, minimal research has been conducted on anxiety-anxiety comorbidity. This study examined factors associated with anxiety comorbidity and anxiety-MDD temporal sequence. METHODS: Online, self-report data were collected from the UK-based GLAD and COPING NBR cohorts (N = 38,775). Logistic regression analyses compared differences in sociodemographic, trauma, and clinical factors between single anxiety, anxiety-anxiety comorbidity, anxiety-MDD (major depressive disorder) comorbidity, and MDD-only. Additionally, anxiety-first and MDD-first anxiety-MDD were compared. Differences in familial risk were assessed in those participants with self-reported family history or genotype data. RESULTS: Anxiety-anxiety and anxiety-MDD had higher rates of self-reported anxiety or depressive disorder diagnoses, younger age of onset, and higher recurrence than single anxiety. Anxiety-MDD displayed greater clinical severity/complexity than MDD only. Anxiety-anxiety had more severe current anxiety symptoms, less severe current depressive symptoms, and reduced likelihood of self-reporting an anxiety/depressive disorder diagnosis than anxiety-MDD. Anxiety-first anxiety-MDD had a younger age of onset, more severe anxiety symptoms, and less likelihood of self-reporting a diagnosis than MDD-first. Minimal differences in familial risk were found. LIMITATIONS: Self-report, retrospective measures may introduce recall bias. The familial risk analyses were likely underpowered. CONCLUSIONS: Anxiety-anxiety comorbidity displayed a similarly severe and complex profile of symptoms as anxiety-MDD but distinct features. For anxiety-MDD, first-onset anxiety had an earlier age of onset and greater severity than MDD-first. Anxiety disorders and comorbidity warrant further investigation and attention in research and practice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.jad.2022.11.051 |
| الإتاحة: | https://doi.org/10.1016/j.jad.2022.11.051Test https://pure.au.dk/portal/da/publications/factors-associated-with-anxiety-disorder-comorbidityTest(8071b1d5-bd2d-4e30-8923-a6a947c04280).html |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E5EE3149 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jad.2022.11.051 |
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