دورية أكاديمية
Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization
| العنوان: | Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization |
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| المؤلفون: | Gormley, Mark, Dudding, Tom, Thomas, Steven J, Tyrrell, Jessica, Ness, Andrew R, Pring, Miranda, Legge, Danny, Smith, George Davey, Richmond, Rebecca C, Vincent, Emma E, Bull, Caroline |
| المصدر: | Gormley , M , Dudding , T , Thomas , S J , Tyrrell , J , Ness , A R , Pring , M , Legge , D , Smith , G D , Richmond , R C , Vincent , E E & Bull , C 2023 , ' Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization ' , eLife , vol. 12 , e82674 . https://doi.org/10.7554/eLife.82674Test |
| سنة النشر: | 2023 |
| المجموعة: | University of Bristol: Bristol Reserach |
| مصطلحات موضوعية: | /dk/atira/pure/core/keywords/population_health_SRI, name=Bristol Population Health Science Institute, /dk/atira/pure/core/keywords/icep, name=ICEP |
| الوصف: | A recent World Health Organization report states that at least 40% of all cancer cases may be preventable, with smoking, alcohol consumption and obesity identified as three of the most important modifiable lifestyle factors. Given the significant decline in smoking rates, particularly within developed countries, other potentially modifiable risk factors for head and neck cancer warrant investigation. Obesity and related metabolic disorders such as type 2 diabetes and hypertension have been associated with head and neck cancer risk in multiple observational studies. However, adiposity has also been correlated with smoking, with bias, confounding or reverse causality possibly explaining these findings. To overcome the challenges of observational studies, we conducted two-sample Mendelian randomization (inverse variance weighted (IVW) method) using genetic variants which were robustly associated with adiposity, glycaemic and blood pressure traits in genome-wide association studies (GWAS). Outcome data was taken from the largest available GWAS of 6,034 oral and oropharyngeal cases, with 6,585 controls. We found limited evidence of a causal effect of genetically proxied body mass index (OR IVW = 0.89, 95%CI 0.72-1.09, p = 0.26 per 1 SD in BMI (4.81 kg/m2)) on oral and oropharyngeal cancer risk. Similarly, there was limited evidence for related traits including type 2 diabetes and hypertension. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research-information.bris.ac.uk/en/publications/f9d2179d-8fd9-4148-8178-7c4eee776eaeTest |
| DOI: | 10.7554/eLife.82674 |
| الإتاحة: | https://doi.org/10.7554/eLife.82674Test https://hdl.handle.net/1983/f9d2179d-8fd9-4148-8178-7c4eee776eaeTest https://research-information.bris.ac.uk/en/publications/f9d2179d-8fd9-4148-8178-7c4eee776eaeTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E5BF9A7E |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/eLife.82674 |
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