التفاصيل البيبلوغرافية
| العنوان: |
Hypochlorous Acid Activating MB‐O to Release Methylene Blue for Photodegrading of Aβ Aggregates |
| المؤلفون: |
Bao, Xinlu, Yao, Yusi, Xu, Yunze, Shen, Yang, Lv, Guanglei, Zhao, Dian, Li, Chunxia |
| المساهمون: |
National Natural Science Foundation of China |
| المصدر: |
Zeitschrift für anorganische und allgemeine Chemie ; volume 647, issue 20-21, page 1992-1996 ; ISSN 0044-2313 1521-3749 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2021 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Amyloid‐β (Aβ) aggregates are one of biomarkers of Alzheimer's disease (AD). It is well known that Aβ aggregates display neurotoxicty or cytotoxicity to neurons. Thus, degrading Aβ aggregates is crucial for exploring the treatment of AD. Moreover, the excessive production of HOCl in the AD brain is an important feature of the disease. Herein, a novel compound MB‐O based on methylene blue (MB) skeleton was designed and synthesized. The probe MB‐O can specifically react with HOCl, releasing the fluorophore MB with strong fluorescence intensity increase. More importantly, the released MB is capable of degrading Aβ aggregates under red light irradiation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/zaac.202100253 |
| الإتاحة: |
https://doi.org/10.1002/zaac.202100253Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.E59C2A1D |
| قاعدة البيانات: |
BASE |
