Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia

التفاصيل البيبلوغرافية
العنوان:	Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
المؤلفون:	Bussy, A, Levy, JP, Best, T, Patel, R, Cupo, L, Van Langenhove, T, Nielsen, JE, Pijnenburg, Y, Waldö, ML, Remes, AM, Schroeter, ML, Anderl‐Straub, S, Rollin, A, Tábuas‐Pereira, M, Kuchcinski, G, Bertoux, M, Lebouvier, T, Deramecourt, V, Russell, LL, Rowe, JB, Timberlake, C, Cantoni, V, Afonso, S, Seelaar, H, Engel, A, Polyakova, M, Bocchetta, M, Rossi, G, Vandenberghe, R, Synofzik, M, Moreno, F, Arighi, A, Todd, E, de Mendonça, A, Sanchez‐Valle, R, van Swieten, JC, Laforce, R, Langheinrich, T, Gerhard, A, Graff, C, Giaccone, G, Shafei, R, Prioni, S, Finger, E, Benotmane, H, Tartaglia, MC, Masellis, M, Di Fede, G, Papma, JM, Devenyi, GA, Convery, RS, Chakravarty, MM, Ducharme, S, Fenoglio, C, Esteve, AS, Bessi, V, Zetterberg, H, Nelson, A, Bouzigues, A, Heller, C, Greaves, CV, Giannini, L, Caroppo, P, Swift, IJ, Scarpini, E, Veldsman, M, Nicholas, J, Jelic, V, Verdelho, A, Cope, T, Tiraboschi, P, Rittman, T, Benussi, A, Andersson, C, Villanua, J, Fumagalli, G, Premi, E, Gasparotti, R, Archetti, S, Gazzina, S, Maruta, C, van Minkelen, R, Borracci, V, Cañada, M, Thonberg, H, Alves, P, Poesen, K, Redaelli, V, Tang‐Wai, D, Rogaeva, E, Tainta, M, Funkiewiez, A, Castelo‐Branco, M, Öijerstedt, L, Freedman, M, Keren, R, Rosa‐Neto, P, Ferreira, CB, Black, S, Mitchell, S, Nacmias, B, Shoesmith, C, Bartha, R, Rademakers, R, Poos, J, Rinaldi, D, Zulaica, M, Prix, C, Ferrari, C, Miltenberger, G, Polito, C, Lombardi, G, Saracino, D, Santiago, B, Thompson, P, Barandiaran, M, Lladó, A, Gauthier, S, Antonell, A, Santana, I, do Couto, FS, Olives, J, Balasa, M, Bargalló, N, Borrego‐Ecija, S, Duro, D, Colliot, O, Gabilondo, A, Camuzat, A, Pasquier, F, Gorostidi, A, Le Ber, I, Butler, CR, Bender, B, Sayah, S, Wilke, C, Graf, L, Otto, M, Brice, A, Vogels, A, Vandenbulcke, M, Van Damme, P, Bruffaerts, R, Sorbi, S, Leitão, MJ, Bertrand, A, Galimberti, D, Danek, A, Rohrer, JD, Cash, D, Wlasich, E, Almeida, MR, Wagemann, O, Loosli, S, Borroni, B, Samra, K, Schönecker, S, Levin, J, Hoegen, T, Lombardi, J, Thomas, DL, Jiskoot, L
المساهمون:	GENetic Frontotemporal dementia Initiative (GENFI)
بيانات النشر:	Wiley
سنة النشر:	2023
المجموعة:	Brunel University London: Brunel University Research Archive (BURA)
مصطلحات موضوعية:	frontotemporal dementia, genetics, magnetic resonance imaging, neuropsychiatry
الوصف:	Data Availability Statement: The data that support the findings of this study are available on request via https://www.genfi.org/studyTest/ or by emailing genfi@ucl.ac.uk. The data are not publicly available due to privacy or ethical restrictions. ; Supporting Information: available online at: https://onlinelibrary.wiley.com/doi/10.1002/hbm.26220#support-information-sectionTest . ; Copyright © 2023 The Authors. Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 ...
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	2684 - 2700; Print-Electronic
اللغة:	English
تدمد:	1065-9471 1097-0193
العلاقة:	Human Brain Mapping; ORCID iDs: Aurélie Bussy orcid:0000-0001-6695-9941; Jørgen E. Nielsen orcid:0000-0003-0453-5582; Barbara Borroni orcid:0000-0001-9340-9814; Martina Bocchetta orcid:0000-0003-1814-5024; Gabriel A. Devenyi orcid:0000-0002-7766-1187.; Bussy, A. et al. on behalf of GENetic Frontotemporal dementia Initiative (GENFI) (2023) 'Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia', Human Brain Mapping, 44 (7), pp. 2684 - 2700. doi:10.1002/hbm.26220.; https://bura.brunel.ac.uk/handle/2438/26192Test; https://doi.org/10.1002/hbm.26220Test
DOI:	10.1002/hbm.26220
الإتاحة:	https://doi.org/10.1002/hbm.26220Test https://bura.brunel.ac.uk/handle/2438/26192Test
حقوق:	Copyright © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; The Authors
رقم الانضمام:	edsbas.E538B095
قاعدة البيانات:	BASE

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تدمد:	10659471 10970193
DOI:	10.1002/hbm.26220