دورية أكاديمية
The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and Their Associations with the Incidence of Postoperative Delirium
| العنوان: | The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and Their Associations with the Incidence of Postoperative Delirium |
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| المؤلفون: | Jung, Mijin, Pan, Xiaobei, Cunningham, Emma L., Passmore, Anthony P., McGuinness, Bernadette, McAuley, Daniel F., Beverland, David, O’brien, Seamus, Mawhinney, Tim, Schott, Jonathan M., Zetterberg, Henrik, Green, Brian D. |
| المصدر: | Jung , M , Pan , X , Cunningham , E L , Passmore , A P , McGuinness , B , McAuley , D F , Beverland , D , O’brien , S , Mawhinney , T , Schott , J M , Zetterberg , H & Green , B D 2022 , ' The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and Their Associations with the Incidence of Postoperative Delirium ' , Metabolites , vol. 12 , no. 7 , 616 . https://doi.org/10.3390/metabo12070616Test |
| سنة النشر: | 2022 |
| المجموعة: | Queen's University Belfast: Research Portal |
| مصطلحات موضوعية: | ornithine, orthopedic surgery, polyamine, postoperative delirium, spermine, /dk/atira/pure/subjectarea/asjc/2700/2712, name=Endocrinology, Diabetes and Metabolism, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes. Participants (n = 54) matched for age and gender were sampled from an observational cohort study investigating postoperative delirium. Participants were ≥65 years without a diagnosis of dementia and presented for primary elective hip or knee arthroplasty. Plasma samples collected pre-and postoperatively were grouped as either control (n = 26, aged: 75.8 ± 5.2) or delirium (n = 28, aged: 76.2 ± 5.7). Widespread changes in plasma metabolite levels occurred following surgery. The only metabolites significantly differing between corresponding control and delirium samples were ornithine and spermine. In delirium cases, ornithine was 17.6% higher preoperatively, and spermine was 12.0% higher postoperatively. Changes were not associated with various perioperative factors. In binary logistic regression modeling, these two metabolites did not confer a significantly increased risk of delirium. These findings support the hypothesis that disturbed polyamine metabolism is an underlying factor in delirium that warrants further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.qub.ac.uk/en/publications/69af6b48-f315-4103-8bd0-ccbff1cdbe73Test |
| DOI: | 10.3390/metabo12070616 |
| الإتاحة: | https://doi.org/10.3390/metabo12070616Test https://pure.qub.ac.uk/en/publications/69af6b48-f315-4103-8bd0-ccbff1cdbe73Test https://pureadmin.qub.ac.uk/ws/files/347192750/metabolites_12_00616.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E4B5036C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/metabo12070616 |
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