دورية أكاديمية
Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial
| العنوان: | Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial |
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| المؤلفون: | Baharoglu, M Irem, Cordonnier, Charlotte, Salman, Rustam Al-Shahi, de Gans, Koen, Koopman, Maria M, Brand, Anneke, Majoie, Charles B, Beenen, Ludo F, Marquering, Henk A, Vermeulen, Marinus, Nederkoorn, Paul J, de Haan, Rob J, Roos, Yvo B, Serge, Timsit |
| المساهمون: | Department of Neurology, Academic Medical Centre, University of Amsterdam, Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Département de neurologie Lille, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Center for Clinical Brain Sciences (CCBS - EDINBURGH), University of Edinburgh (Edin.), Department of Neurology, Groene Hart Hospital Gouda, Sanquin Bloodbank, Department of Radiology (Dep Radio - AMSTERDAM), Academic Medical Center - Academisch Medisch Centrum Amsterdam (AMC), University of Amsterdam Amsterdam = Universiteit van Amsterdam (UvA)-University of Amsterdam Amsterdam = Universiteit van Amsterdam (UvA), Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam Amsterdam = Universiteit van Amsterdam (UvA), Clinical Research Unit (CRU - AMSTERDAM), Service de Neurologie Brest, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0140-6736. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2016 |
| المجموعة: | Université de Bretagne Occidentale: HAL |
| مصطلحات موضوعية: | [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Platelet transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet therapy might reduce death or dependence by reducing the extent of the haemorrhage. We aimed to investigate whether platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet therapy use. ; We did this multicentre, open-label, masked-endpoint, randomised trial at 60 hospitals in the Netherlands, UK, and France. We enrolled adults within 6 h of supratentorial intracerebral haemorrhage symptom onset if they had used antiplatelet therapy for at least 7 days beforehand and had a Glasgow Coma Scale score of at least 8. With use of a secure web-based system that concealed allocation and used biased coin randomisation, study collaborators randomly assigned participants (1:1; stratified by hospital and type of antiplatelet therapy) to receive either standard care or standard care with platelet transfusion within 90 min of diagnostic brain imaging. Participants and local investigators giving interventions were not masked to treatment allocation, but allocation was concealed from outcome assessors and investigators analysing data. The primary outcome was shift towards death or dependence rated on the modified Rankin Scale (mRS) at 3 months, and analysed by ordinal logistic regression, adjusted for stratification variables and the Intracerebral Haemorrhage Score. The primary analysis was done in the intention-to-treat population and safety analyses were done in the intention-to-treat and as-treated populations. This trial is registered with the Netherlands Trial Register, number NTR1303, and is now closed. ; Between Feb 4, 2009, and Oct 8, 2015, 41 sites enrolled 190 participants. 97 participants were randomly assigned to platelet transfusion and 93 to standard care. The odds of death or dependence at 3 months were higher in the platelet transfusion group than in the standard care group ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27178479; hal-01561017; https://hal.univ-brest.fr/hal-01561017Test; PUBMED: 27178479 |
| DOI: | 10.1016/S0140-6736(16)30392-0 |
| الإتاحة: | https://doi.org/10.1016/S0140-6736Test(16)30392-0 https://hal.univ-brest.fr/hal-01561017Test |
| رقم الانضمام: | edsbas.E49D011A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0140-6736(16)30392-0 |
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