دورية أكاديمية
Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease.
| العنوان: | Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease. |
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| المؤلفون: | Morenas-Rodríguez, Estrella, Alcolea, Daniel, Ribosa-Nogué, Roser, Blesa, Rafael, Haass, Christian, Fortea, Juan, Lleó, Alberto, Suárez-Calvet, Marc, Muñoz-Llahuna, Laia, Vilaplana, Eduard, Sala, Isabel, Subirana, Andrea, Querol-Vilaseca, Marta, Carmona-Iragui, María, Illán-Gala, Ignacio |
| المصدر: | Scientific reports 9(1), 7803 (2019). doi:10.1038/s41598-019-44173-8 |
| بيانات النشر: | Macmillan Publishers Limited, part of Springer Nature |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/600, Aged, 80 and over, Alzheimer Disease: cerebrospinal fluid, Alzheimer Disease: pathology, Amyloid beta-Peptides: cerebrospinal fluid, Biomarkers: cerebrospinal fluid, Chitinase-3-Like Protein 1: cerebrospinal fluid, Female, Humans, Lewy Body Disease: cerebrospinal fluid, Lewy Body Disease: pathology, Male, Membrane Glycoproteins: cerebrospinal fluid, Middle Aged, Neuroglia: pathology, Peptide Fragments: cerebrospinal fluid, Progranulins: cerebrospinal fluid, Receptors, Immunologic |
| جغرافية الموضوع: | DE |
| الوصف: | The role of innate immunity in dementia with Lewy bodies (DLB) has been little studied. We investigated the levels in cerebrospinal fluid (CSF) of glial proteins YKL-40, soluble TREM2 (sTREM2) and progranulin in DLB and their relationship with Alzheimer's disease (AD) biomarkers. We included patients with DLB (n = 37), prodromal DLB (prodDLB, n = 23), AD dementia (n = 50), prodromal AD (prodAD, n = 53), and cognitively normal subjects (CN, n = 44). We measured levels of YKL-40, sTREM2, progranulin, Aβ1-42, total tau (t-tau) and phosphorylated tau (p-tau) in CSF. We stratified the group DLB according to the ratio t-tau/Aβ1-42 (≥0.52, indicative of AD pathology) and the A/T classification. YKL-40, sTREM2 and progranulin levels did not differ between DLB groups and CN. YKL-40 levels were higher in AD and prodAD compared to CN and to DLB and prodDLB. Patients with DLB with a CSF profile suggestive of AD copathology had higher levels of YKL-40, but not sTREM2 or PGRN, than those without. T+ DLB patients had also higher YKL-40 levels than T-. Of these glial markers, only YKL-40 correlated with t-tau and p-tau in DLB and in prodDLB. In contrast, in prodAD, sTREM2 and PGRN also correlated with t-tau and p-tau. In conclusion, sTREM2 and PGRN are not increased in the CSF of DLB patients. YKL-40 is only increased in DLB patients with an AD biomarker profile, suggesting that the increase is driven by AD-related neurodegeneration. These data suggest a differential glial activation between DLB and AD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:31127154; info:eu-repo/semantics/altIdentifier/issn/2045-2322; https://pub.dzne.de/record/140714Test; https://pub.dzne.de/search?p=id:%22DZNE-2020-07036%22Test |
| الإتاحة: | https://doi.org/10.1038/s41598-019-44173-8Test https://pub.dzne.de/record/140714Test https://pub.dzne.de/search?p=id:%22DZNE-2020-07036%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E4794C6F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |