دورية أكاديمية
The safety of low-molecular-weight heparins in the prevention of venous thromboembolism in surgically-treated cancer patients: results of a multicentre observational study
| العنوان: | The safety of low-molecular-weight heparins in the prevention of venous thromboembolism in surgically-treated cancer patients: results of a multicentre observational study |
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| المؤلفون: | Tomasz Olesiński, Anna Fijałkowska, Andrzej Rutkowski |
| المصدر: | Contemporary Oncology, Vol 21, Iss 2, Pp 152-156 (2017) |
| بيانات النشر: | Termedia Publishing House |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | venous thromboembolism, pharmacological prophylaxis, low-molecular-weight heparins, Medicine |
| الوصف: | Aim of the study : Despite widespread use of pharmacological prophylaxis, venous thromboembolism (VTE) still constitutes a common complication in cancer patients. The aim of the study was to analyse the safety of low-molecular-weight heparins (LMWH) in the prevention of VTE in surgically-treated cancer patients. Material and methods : A total of 5207 cancer patients (44.5% men and 55.5% women) aged 16–97 years participated in a prospective observational study conducted in 13 Polish cancer centres in 2005–2008. This cohort included 4782 subjects who were treated surgically and received LMWH as a pharmacological prophylaxis for VTE prior to or after the surgery. The incidence of haemorrhagic complications and thrombocytopaenia was analysed in this cohort, along with intra-hospital mortality. Results: Mean duration of LMWH administration was 9.4 ±7.8 days. Haemorrhagic complications: heavy (n = 15) or light bleeding (n = 299), were observed in 314 patients (6.5%). A total of 314 patients (6.5%) presented with haemorrhagic complications: heavy (n = 15, 0.3%) or light bleeding (n = 299, 6.3%). Four cases of heavy bleeding: gastrointestinal bleeding (n = 2), retroperitoneal bleeding (n = 1), and central nervous system bleeding (n = 1), were classified as definitely related to LMWH. No significant association was found between the incidence of haemorrhagic complications and the type of administered LWMH (p = 0.523). No cases of thrombocytopaenia or deaths related to administration of LMWH were reported. Conclusions : LMWH seems to be a safe form of pharmacological prophylaxis for VTE in surgically-treated cancer patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1428-2526 1897-4309 |
| العلاقة: | https://www.termedia.pl/The-safety-of-low-molecular-weight-heparins-in-the-prevention-of-venous-thromboembolism-in-surgically-treated-cancer-patients-results-of-a-multicentre-observational-study,3,30176,1,1.htmlTest; https://doaj.org/toc/1428-2526Test; https://doaj.org/toc/1897-4309Test; https://doaj.org/article/5c415a9a0ef846d883ef134417aebb76Test |
| DOI: | 10.5114/wo.2017.68624 |
| الإتاحة: | https://doi.org/10.5114/wo.2017.68624Test https://doaj.org/article/5c415a9a0ef846d883ef134417aebb76Test |
| رقم الانضمام: | edsbas.E46B3EE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14282526 18974309 |
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| DOI: | 10.5114/wo.2017.68624 |