دورية أكاديمية
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Transcriptomic and connectomic correlates of differential spatial patterning among gliomas

التفاصيل البيبلوغرافية
العنوان: Transcriptomic and connectomic correlates of differential spatial patterning among gliomas
المؤلفون: Romero García, Rafael, Mandal, Ayan, Bethlehem, Richard A. I., Crespo-Facorro, Benedicto, Hart, Michael G., Suckling, John
المساهمون: Junta de Andalucía, Cancer Research UK, Universidad de Sevilla, Romero Garcia, Rafael, Mandal, Ayan
بيانات النشر: Oxford University Press
سنة النشر: 2023
المجموعة: Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council)
مصطلحات موضوعية: Connectomic, Gene expression, Glioma, Transcriptomic
الوصف: Unravelling the complex events driving grade-specific spatial distribution of brain tumour occurrence requires rich datasets from both healthy individuals and patients. Here, we combined open-access data from The Cancer Genome Atlas, the UK Biobank and the Allen Brain Human Atlas to disentangle how the different spatial occurrences of glioblastoma multiforme and low-grade gliomas are linked to brain network features and the normative transcriptional profiles of brain regions. From MRI of brain tumour patients, we first constructed a grade-related frequency map of the regional occurrence of low-grade gliomas and the more aggressive glioblastoma multiforme. Using associated mRNA transcription data, we derived a set of differential gene expressions from glioblastoma multiforme and low-grade gliomas tissues of the same patients. By combining the resulting values with normative gene expressions from post-mortem brain tissue, we constructed a grade-related expression map indicating which brain regions express genes dysregulated in aggressive gliomas. Additionally, we derived an expression map of genes previously associated with tumour subtypes in a genome-wide association study (tumour-related genes). There were significant associations between grade-related frequency, grade-related expression and tumour-related expression maps, as well as functional brain network features (specifically, nodal strength and participation coefficient) that are implicated in neurological and psychiatric disorders. These findings identify brain network dynamics and transcriptomic signatures as key factors in regional vulnerability for glioblastoma multiforme and low-grade glioma occurrence, placing primary brain tumours within a well established framework of neurological and psychiatric cortical alterations. ; R.R.-G. is funded by a non-clinical post-doctoral Brain fellowship, the EMERGIA Junta de Andalucía program (EMERGIA20_00139) and Cancer Research UK Cambridge Centre (grant ref. A25117) and the Plan Propio of the University of ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 0006-8950
1460-2156
العلاقة: Publisher's version; Romero Garcia, Rafael; Mandal, Ayan; Bethlehem, Richard, A. I.; Crespo-Facorro, Benedicto; Hart, Michael G.; Suckling, John; 2023; Transcriptomic and connectomic correlates of differential spatial patterning among gliomas Supplementary Material [Dataset]; Oxford University Press; https://doi.org/10.1093/brain/awac378Test; https://doi.org/10.1093/brain/awac378Test; Sí; Brain 146(3): 1200-1211 (2023); http://hdl.handle.net/10261/340125Test; http://dx.doi.org/10.13039/100009042Test; http://dx.doi.org/10.13039/501100000289Test; http://dx.doi.org/10.13039/501100011011Test; 2-s2.0-85149185577; https://api.elsevier.com/content/abstract/scopus_id/85149185577Test
DOI: 10.1093/brain/awac378
DOI: 10.13039/100009042
DOI: 10.13039/501100000289
DOI: 10.13039/501100011011
الإتاحة: https://doi.org/10.1093/brain/awac37810.13039/10000904210.13039/50110000028910.13039/501100011011Test
http://hdl.handle.net/10261/340125Test
https://api.elsevier.com/content/abstract/scopus_id/85149185577Test
حقوق: open
رقم الانضمام: edsbas.E3F2948A
قاعدة البيانات: BASE
الوصف
تدمد:00068950
14602156
DOI:10.1093/brain/awac378