دورية أكاديمية
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
| العنوان: | Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth |
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| المؤلفون: | Beaumont, RN, Flatley, C, Vaudel, M, Wu, X, Chen, J, Moen, G-H, Skotte, L, Helgeland, Ø, Solé-Navais, P, Banasik, K, Albiñana, C, Ronkainen, J, Fadista, J, Stinson, SE, Trajanoska, K, Wang, CA, Westergaard, D, Srinivasan, S, Sánchez-Soriano, C, Bilbao, JR, Allard, C, Groleau, M, Kuulasmaa, T, Leirer, DJ, White, F, Jacques, P-É, Cheng, H, Hao, K, Andreassen, OA, Åsvold, BO, Atalay, M, Bhatta, L, Bouchard, L, Brumpton, BM, Brunak, S, Bybjerg-Grauholm, J, Ebbing, C, Elliott, P, Engelbrechtsen, L, Erikstrup, C, Estarlich, M, Franks, S, Gaillard, R, Geller, F, Grove, J, Hougaard, DM, Kajantie, E, Morgen, CS, Nohr, EA, Nyegaard, M, Palmer, CNA, Pedersen, OB, Rivadeneira, F, Sebert, S, Shields, BM, Stoltenberg, C, Surakka, I, Thørner, LW, Ullum, H, Vaarasmaki, M, Vilhjalmsson, BJ, Willer, CJ, Lakka, TA, Gybel-Brask, D, Bustamante, M, Hansen, T, Pearson, ER, Reynolds, RM, Ostrowski, SR, Pennell, CE, Jaddoe, VWV, Felix, JF, Hattersley, AT, Melbye, M, Lawlor, DA, Hveem, K, Werge, T, Nielsen, HS, Magnus, P, Evans, DM, Jacobsson, B, Järvelin, M-R, Zhang, G, Hivert, M-F, Johansson, S, Freathy, RM, Feenstra, B, Njølstad, PR |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2023 |
| المجموعة: | University of Exeter: Open Research Exeter (ORE) |
| الوصف: | This is the final version. Available on open access from Nature Research via the DOI in this record. ; Data availability: Individual cohorts contributing to the meta-analysis should be contacted directly as each cohort has different data access policies. GWAS summary statistics from this study are available via the EGG website (https://egg-consortium.org/placental-weight-2023.htmlTest, https://www.ebi.ac.uk/gwasTest/), as well as the GWAS catalog (https://www.ebi.ac.uk/gwasTest/, accession numbers GCST90275189, GCST90275190, GCST90275191, GCST90275192, GCST90275193, GCST90275194, GCST90275195, GCST90275196, GCST90275197, GCST90275198, GCST90275199). Access to personal-level information from Gen3G (including methylation array data) is subject to controlled access according to participants’ consent concerning sharing of personal data. Request for conditions of access and for data access should be addressed to Center Hospitalier Universitaire de Sherbrooke institutional ethics committee: ethique.recherche.ciussse-chus@ssss.gouv.qc.ca. ; Code availability: Analysis code is available from https://github.com/EarlyGrowthGenetics/placental_weight_codeTest ; A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1061-4036 1546-1718 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pubmed/37798380Test; https://egg-consortium.org/placental-weight-2023.htmlTest; https://www.ebi.ac.uk/gwasTest/; https://github.com/EarlyGrowthGenetics/placental_weight_codeTest; Nat Genet; orcid:0000-0003-0750-8248 (Beaumont, Robin N); orcid:0000-0001-5620-473X (Hattersley, Andrew T); orcid:0000-0003-4152-2238 (Freathy, Rachel M); Published online 5 October 2023; https://doi.org/10.1038/s41588-023-01520-wTest; WT104150; WT220390; http://hdl.handle.net/10871/134326Test; Nature Genetics |
| DOI: | 10.1038/s41588-023-01520-w |
| الإتاحة: | https://doi.org/10.1038/s41588-023-01520-wTest http://hdl.handle.net/10871/134326Test |
| حقوق: | © The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.E3CE916E |
| قاعدة البيانات: | BASE |
| تدمد: | 10614036 15461718 |
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| DOI: | 10.1038/s41588-023-01520-w |