التفاصيل البيبلوغرافية
| العنوان: |
Treosulfan compared to busulfan in allogeneic haematopoietic stem cell transplantation for myelofibrosis: a registry-based study from the Chronic Malignancies Working Party of the EBMT |
| المؤلفون: |
Robin, M., Iacobelli, S., Koster, L., Passweg, J., Avenoso, D., Wilson, K.M.O., Salmenniemi, U., Dreger, P., von dem Borne, P., Snowden, J.A., Robinson, S., Finazzi, M.C., Schroeder, T., Collin, M., Eder, M., Forcade, E., Loschi, M., Bramanti, S., Pérez-Simón, J.A., Czerw, T., Polverelli, N., Drozd-Sokolowska, J., Raj, K., Hernández-Boluda, J.C., McLornan, D.P. |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2024 |
| المجموعة: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| الوصف: |
We aimed to compare outcomes following treosulfan (TREO) or busulfan (BU) conditioning in a large cohort of myelofibrosis (MF) patients from the EBMT registry. A total of 530 patients were included; 73 received TREO and 457 BU (BU ≤ 6.4 mg/kg in 134, considered RIC, BU > 6.4 mg/kg in 323 considered higher dose (HD)). Groups were compared using adjusted Cox models. Cumulative incidences of engraftment and acute GVHD were similar across the 3 groups. The TREO group had significantly better OS than BU-HD (HR:0.61, 95% CI: 0.39-0.93) and a trend towards better OS over BU-RIC (HR: 0.66, 95% CI: 0.41-1.05). Moreover, the TREO cohort had a significantly better Progression-Free-Survival (PFS) than both the BU-HD (HR: 0.57, 95% CI: 0.38-0.84) and BU-RIC (HR: 0.60, 95% CI: 0.39-0.91) cohorts, which had similar PFS estimates. Non-relapse mortality (NRM) was reduced in the TREO and BU-RIC cohorts (HR: 0.44, 95% CI: 0.24-0.80 TREO vs BU-HD; HR: 0.54, 95% CI: 0.28-1.04 TREO vs BU-RIC). Of note, relapse risk did not significantly differ across the three groups. In summary, within the limits of a registry-based study, TREO conditioning may improve PFS in MF HSCT and have lower NRM than BU-HD with a similar relapse risk to BU-RIC. Prospective studies are needed to confirm these findings. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
Robin, M. orcid.org/0000-0003-1388-9876 , Iacobelli, S., Koster, L. et al. (22 more authors) (2024) Treosulfan compared to busulfan in allogeneic haematopoietic stem cell transplantation for myelofibrosis: a registry-based study from the Chronic Malignancies Working Party of the EBMT. Bone Marrow Transplantation. ISSN 0268-3369 |
| الإتاحة: |
https://eprints.whiterose.ac.uk/211132Test/ |
| رقم الانضمام: |
edsbas.E3CBF64F |
| قاعدة البيانات: |
BASE |
