دورية أكاديمية
Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study.
| العنوان: | Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study. |
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| المؤلفون: | Fuchs, A., Disma, N., Virág, K., Ulmer, F., Habre, W., de Graaff, J.C., Riva, T. |
| المساهمون: | NECTARINE Group of the European Society of Anaesthesiology and Intensive Care Clinical Trial Network, Breschan, C., Likar, R., Platzer, M., Edelman, I., Eger, J., Heschl, S., Messerer, B., Vittinghof, M., Kroess, R., Stichlberger, M., Kahn, D., Pirotte, T., Pregardien, C., Veyckemans, F., Stevens, F., Berghmans, J., Bauters, A., De Baerdemaeker, L., De Hert, S., Lapage, K., Parashchanka, A., Van Limmen, J., Wyffels, P., Najafi, N., Vundelinckx, J., Butković, D., Sorić, I.K., Kralik, S., Markić, A., Azman, J., Markic, J., Pupacic, D., Frelich, M., Reimer, P., Urbanec, R., Cajková, P., Mixa, V., Sedláčková, Y., Knoppová, L., Zlámalová, A., Vavřina, M., Žurek, J., Hansen, T., Afshari, A., Bille, A.B., Ellekvist, M., Ilmoja, M.L., Moor, R., Kikas, R., Väli, M., Kallio, K., Reponen, E., Suominen, P., Suvanto, S., Vähätalo, R., Kokki, H., Kokki, M., Harju, J., Kokkonen, M., Vieri, J., Manner, T., Amory, C., Ludot, H., Bert, D., Godart, J., Laffargue, A., Dupont, H., Urbina, B., Baujard, C., Roulleau, P., Staiti, G., Bordes, M., Gaulain, K.N., Hamonic, Y., Semjen, F., Jacqmarcq, O., Lejus-Bourdeau, C., Magne, C., Petry, L., Ros, L., Zang, A., Bennis, M., Coustets, B., Fesseau, R., Constant, I., Khalil, E., Sabourdin, N., Audren, N., Descarpentries, T., Fabre, F., Legrand, A., Druot, E., Orliaguet, G., Sabau, L., Uhrig, L., de la Brière, F., Jonckheer, K., Mission, J.P., Scordo, L. |
| المصدر: | European journal of anaesthesiology, vol. 39, no. 3, pp. 252-260 |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Anesthesia/adverse effects, Erythrocyte Transfusion, Europe, Hemoglobins/analysis, Humans, Infant, Newborn, Prospective Studies |
| الوصف: | Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. A multicentre observational study. The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. ClinicalTrials.gov, identifier: NCT02350348. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0265-0215 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34845167; info:eu-repo/semantics/altIdentifier/eissn/1365-2346; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_20917ACDD1076; https://serval.unil.ch/notice/serval:BIB_20917ACDD107Test; urn:issn:0265-0215; https://serval.unil.ch/resource/serval:BIB_20917ACDD107.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_20917ACDD1076Test |
| DOI: | 10.1097/EJA.0000000000001646 |
| الإتاحة: | https://doi.org/10.1097/EJA.0000000000001646Test https://serval.unil.ch/notice/serval:BIB_20917ACDD107Test https://serval.unil.ch/resource/serval:BIB_20917ACDD107.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_20917ACDD1076Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimerTest |
| رقم الانضمام: | edsbas.E3BA3F05 |
| قاعدة البيانات: | BASE |
| تدمد: | 02650215 |
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| DOI: | 10.1097/EJA.0000000000001646 |