دورية أكاديمية
Genome sequence, comparative analysis, and population genetics of the domestic horse
| العنوان: | Genome sequence, comparative analysis, and population genetics of the domestic horse |
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| المؤلفون: | Wade, C., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., Lear, T., Adelson, D., Bailey, E., Bellone, R., Blocker, H., Distl, O., Edgar, R., Garber, M., Leeb, T., Mauceli, E., Macleod, J., PENEDO, M., Raison, J., Sharpe, T. |
| المصدر: | http://dx.doi.org/10.1126/science.1178158Test. |
| بيانات النشر: | Amer Assoc Advancement Science |
| سنة النشر: | 2009 |
| المجموعة: | The University of Adelaide: Digital Library |
| مصطلحات موضوعية: | Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Chromosomes, Mammalian, Centromere, Animals, Domestic, Dogs, Horses, Humans, Chromosome Mapping, Sequence Analysis, DNA, Computational Biology, Evolution, Molecular, Phylogeny, Repetitive Sequences, Nucleic Acid, Synteny, Haplotypes, Genes, Genome, Molecular Sequence Data, Female, DNA Copy Number Variations |
| الوصف: | We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds. ; C. M. Wade. D. L. Adelson. J. M. Raison. et al. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0036-8075 1095-9203 |
| العلاقة: | Science, 2009; 326(5954):865-867; http://hdl.handle.net/2440/57814Test; Adelson, D. [0000-0003-2404-5636] |
| DOI: | 10.1126/science.1178158 |
| الإتاحة: | https://doi.org/10.1126/science.1178158Test http://hdl.handle.net/2440/57814Test |
| رقم الانضمام: | edsbas.E3AAC19A |
| قاعدة البيانات: | BASE |
| تدمد: | 00368075 10959203 |
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| DOI: | 10.1126/science.1178158 |