التفاصيل البيبلوغرافية
| العنوان: |
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study |
| المؤلفون: |
Ravlo, Erlend, Ianevski, Aleksandr, Starheim, Eirin, Wang, Wei, Ji, Ping, Lysvand, Hilde, Smura, Teemu, Kivi, Gaily, Voolaid, Maia-Liisa, Plaan, Kati, Ustav, Mart, Ustav Jr, Mart, Zusinaite, Eva, Tenson, Tanel, Kurg, Reet, Oksenych, Valentyn, Walstad, Kirsti, Nordba, Svein Arne, Kaarba, Mari, Ernits, Karin, Bjaras, Magnar, Kainov, Denis E., Fenstad, Mona Haysaeter |
| المساهمون: |
Department of Virology, HUSLAB, HUS Diagnostic Center, Institute for Molecular Medicine Finland, Department of Computer Science, University of Helsinki |
| بيانات النشر: |
Elsevier Ltd. |
| سنة النشر: |
2023 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Covid-19, Immune response, Neutralizing antibody, SARS-CoV-2, mRNA vaccination, 3121 General medicine, internal medicine and other clinical medicine |
| الوصف: |
Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how messenger RNA (mRNA) vaccination of convalescents provides protection from emerging virus variants. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine encoding spike (S) protein of strain of 19A clade. We showed that vaccination increased the production of immune cells and anti-S antibodies in the serum. Serum antibodies neutralized not only 19A and 20A, but also 20B, 20H, 21J, and 21K virus variants. One of the serum antibodies (100F8) completely neutralized 20A, 21J, and partially 21K strains. 100F8 was structurally similar to published Ab188 antibody, which recognized non-conserved epitope on the S protein. We proposed that 100F8 and other serum antibodies of the patient which recognized non- and conserved epitopes of the S protein, could have additive or synergistic effects to neutralize various virus variants. Thus, mRNA vaccination could be beneficial for convalescents because it boosts production of neutralizing antibodies with broad-spectrum activity. (c) 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0Test/ ) ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Ravlo , E , Ianevski , A , Starheim , E , Wang , W , Ji , P , Lysvand , H , Smura , T , Kivi , G , Voolaid , M-L , Plaan , K , Ustav , M , Ustav Jr , M , Zusinaite , E , Tenson , T , Kurg , R , Oksenych , V , Walstad , K , Nordba , S A , Kaarba , M , Ernits , K , Bjaras , M , Kainov , D E & Fenstad , M H 2023 , ' Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study ' , International Journal of Infectious Diseases , vol. 137 , pp. 75-78 . https://doi.org/10.1016/j.ijid.2023.10.011Test; 9b050f05-220d-4220-9fd6-8793004b5265; http://hdl.handle.net/10138/568052Test; 001104000200001 |
| الإتاحة: |
http://hdl.handle.net/10138/568052Test |
| حقوق: |
cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.E3A87438 |
| قاعدة البيانات: |
BASE |
