دورية أكاديمية
Differential Impact of Tumor-infiltrating Immune Cells on Basal and Luminal Cells: Implications for Tumor Invasion and Metastasis
| العنوان: | Differential Impact of Tumor-infiltrating Immune Cells on Basal and Luminal Cells: Implications for Tumor Invasion and Metastasis |
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| المؤلفون: | Song, Guohong, Hsiao, Hsuan, Wang, Jinlian L., Mannion, Ciaran, Stojadinovic, Alexander, Avital, Itzhak, Fu, Sidney W., Mason, Jeffrey, Chen, Wen, Jewett, Anahid, Li, Huiping, Man, Yan-Gao |
| المساهمون: | Song, GH (reprint author), Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China., Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Dept Breast Oncol, Beijing, Peoples R China., Chung Shan Med Univ, Sch Med, Taichung, Taiwan., Changhua Christian Hosp, Dept Obstet & Gynecol, Changhua, Taiwan., Icahn Sch Med Mt Sinai, Genet & Genom Dept, New York, NY 10029 USA., Hackensack Univ, Med Ctr, Dept Pathol, Hackensack, NJ USA., Bon Secours Hlth Syst, Bon Secours Canc Inst, Richmond, VA USA., George Washington Univ, Med Ctr, Dept Med, Washington, DC 20037 USA., George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA., Vet Affairs Med Ctr, Lab Prote & Prot Sci, Baltimore, MD USA., Vet Affairs Med Ctr, Dept Pathol, Washington, DC 20422 USA., Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Dent, Tumor Immunol Lab,Div Oral Biol & Med, Los Angeles, CA 90024 USA., Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | anticancer research |
| سنة النشر: | 2014 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Tumor-infiltrating immune cells, basal cells, stem cells, degeneration, proliferation, RESULTANT AUTO-IMMUNOREACTIONS, ENDOTHELIAL GROWTH-FACTOR, MAMMARY EPITHELIAL-CELLS, BREAST-CANCER CELLS, MYOEPITHELIAL CELLS, COLORECTAL-CANCER, HUMAN PROSTATE, T-CELLS, MESENCHYMAL TRANSITION, FOCAL DEGENERATION |
| الوصف: | Background/Aim: Regarding the impact of tumorinfiltrating immune cells on tumor cells, many contradictory reports have been published. We have hypothesized that these controversies result from differences in tissue types and tumor stages, in which immune cells are variably distributed and differentially associated with epithelial cells. Our current study compared the pattern and frequency of physical association of tumor-infiltrating immune cells with different parenchymal cells of human breast and prostate tumors harboring normal, hyperplastic, in situ, and invasive components. Materials and Methods: The cytological, biological, and molecular alterations were assessed with double immunohistochemistry, double fluorescent labeling, apoptosis assay, and gene expression profiling. Results: Our study detected several previously undescribed features: (i) over 95% of infiltrating immune cells were seen within normal, hyerplastic, or in situ cancer structures with focally-disrupted capsules, and fewer than 5% were found within invasive cancer; (ii) over 95% of normal, hyperplastic, and in situ cancerous epithelial cells were physically shielded from immune cells by the surrounding myoepithelial or basal cell layer; (iii) about 90% of myoepithelial or basal cells physically associated with immune cells and such residual cells within focally disrupted layers exhibited distinct degeneration, including apoptosis, necrosis, and reduced expression of tumor suppressor p63; (iv) epithelial cells overlying focally disrupted tumor capsules surrounded by immune cells had substantially higher proliferation than their adjacent counterparts, and some of the proliferating cells were arranged as tongue-like projections invading the stroma; and (v) microdissected cells overlying focally disrupted tumor capsules had more than 5-fold higher expression of stem cell lineage markers KIT and NCOR2. Conclusion: Tumor-infiltrating immune cells are primarily associated with degenerated myoepithelial or basal cells causing focal disruptions of ... |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0250-7005 1791-7530 |
| العلاقة: | ANTICANCER RESEARCH.2014,34,(11),6363-6380.; 650933; http://hdl.handle.net/20.500.11897/341635Test; WOS:000344961300015 |
| الإتاحة: | https://doi.org/20.500.11897/341635Test https://hdl.handle.net/20.500.11897/341635Test |
| رقم الانضمام: | edsbas.E3826A08 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02507005 17917530 |
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