دورية أكاديمية
Field performance of the malaria highly sensitive rapid diagnostic test in a setting of varying malaria transmission
| العنوان: | Field performance of the malaria highly sensitive rapid diagnostic test in a setting of varying malaria transmission |
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| المؤلفون: | Mwesigwa, J, Slater, H, Bradley, J, Saidy, B, Ceesay, F, Whittaker, C, Kandeh, B, Nkwakamna, D, Drakeley, C, Van Geertruyden, J-P, Bousema, T, Achan, J, D'Alessandro, U |
| المصدر: | 13 ; 1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2019 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Parasitology, Tropical Medicine, Highly sensitive rapid diagnostic test, Malaria, Mass testing and treatment, Plasmodium falciparum, Transmission areas, PLASMODIUM-FALCIPARUM MALARIA, ANTIGEN REACTIVITY, SOUTHERN ZAMBIA, ELIMINATION, PANMALARIAL, INFECTIONS, IMPACT, VIVAX, HRP2, Adolescent, Adult, Aged, 80 and over, Child, Preschool, Cross-Sectional Studies, Diagnostic Tests, Routine, Female, Gambia |
| الوصف: | Background The Gambia has successfully reduced malaria transmission. The human reservoir of infection could further decrease if malaria-infected individuals could be identified by highly sensitive, field-based, diagnostic tools and then treated. Methods A cross-sectional survey was done at the peak of the 2017 malaria season in 47 Gambian villages. From each village, 100 residents were randomly selected for finger-prick blood samples to detect Plasmodium falciparum infections using highly sensitive rapid diagnostic tests (HS-RDT) and PCR. The sensitivity and specificity of the HS-RDT were estimated (assuming PCR as the gold standard) across varying transmission intensities and in different age groups. A deterministic, age-structured, dynamic model of malaria transmission was used to estimate the impact of mass testing and treatment (MTAT) with HS-RDT in four different scenarios of malaria prevalence by PCR: 5, 15, 30, and 60%, and with seasonal transmission. The impact was compared both to MTAT with conventional RDT and mass drug administration (MDA). Results Malaria prevalence by HS-RDT was 15% (570/3798; 95% CI 13.9–16.1). The HS-RDT sensitivity and specificity were 38.4% (191/497, 95% CI 34.2–42.71) and 88.5% (2922/3301; 95% CI 87.4–89.6), respectively. Sensitivity was the highest (50.9%, 95% CI 43.3–58.5%) in high prevalence villages (20–50% by PCR). The model predicted that in very low transmission areas (≤ 5%), three monthly rounds of MTAT with HS-RDT, starting towards the end of the dry season and testing 65 or 85% of the population for 2 consecutive years, would avert 62 or 78% of malaria cases (over 2 years), respectively. The effect of the intervention would be lower in a moderate transmission setting. In all settings, MDA would be superior to MTAT with HS-RDT which would be superior to MTAT with conventional RDT. Conclusion The HS-RDT’s field sensitivity was modest and varied by transmission intensity. In low to very low transmission areas, three monthly rounds per year of MTAT with HS-RDT at 85% ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1475-2875 |
| العلاقة: | Malaria Journal; http://hdl.handle.net/10044/1/76448Test |
| DOI: | 10.1186/s12936-019-2929-1 |
| الإتاحة: | https://doi.org/10.1186/s12936-019-2929-1Test http://hdl.handle.net/10044/1/76448Test |
| حقوق: | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.orgTest/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated |
| رقم الانضمام: | edsbas.E3652050 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14752875 |
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| DOI: | 10.1186/s12936-019-2929-1 |