دورية أكاديمية
Baseline findings from the Anal Cancer Examination (ACE) study: Screening using digital ano-rectal examination in HIV-positive men who have sex with men
| العنوان: | Baseline findings from the Anal Cancer Examination (ACE) study: Screening using digital ano-rectal examination in HIV-positive men who have sex with men |
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| المؤلفون: | Ong, JJ, Grulich, A, Walker, S, Hoy, J, Read, T, Bradshaw, C, Garland, SM, Hillman, R, Templeton, D, Hocking, J, Eu, B, Tee, BK, Fairley, CK |
| المصدر: | urn:ISSN:0969-1413 ; urn:ISSN:1475-5793 ; Journal of Medical Screening, 23, 2, 70-76 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2016 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | Behavioral and Social Science, Sexual and Gender Minorities (SGM/LGBT*), Clinical Research, HIV/AIDS, Prevention, Health Services, Cancer, Clinical Trials and Supportive Activities, Infection, 3 Good Health and Well Being, Anal Canal, Anus Neoplasms, Australia, Digital Rectal Examination, Early Detection of Cancer, HIV Infections, Homosexuality, Male, Humans, Middle Aged, Patient Acceptance of Health Care, Surveys and Questionnaires, HIV, anal cancer, digital ano-rectal examination, men who have sex with men, tertiary screening, anzsrc-for: 1117 Public Health and Health Services |
| الوصف: | Objective: Cytological screening for anal cancer precursors is not always possible. We investigated digital ano-rectal examination (DARE) as a means of early anal cancer detection in HIV-positive men who have sex with men (MSM). Methods: We recruited 327 HIV-positive MSM aged 35 and over from clinics with HIV physicians in Melbourne, Australia, to receive an annual DARE. We analyzed baseline data from patient questionnaires regarding general, anal and sexual health, adverse effects from the anal examination, cancer worry, and quality of life. Results: The majority of men (82%, 95% CI:78–87) felt relaxed during the DARE, 1% (95% CI:0–3) complained of pain, and 1% (95% CI:0–4) reported bleeding after the examination. Nearly all men (99%, 95% CI:96–100) were willing to continue with an annual DARE. Quality of life was unaffected with utility scores of 0.76 before examination vs. 0.77 two weeks after examination, (p=0.41). An anal abnormality was detected in 86 men (27%, 95% CI:22–31), with one anal cancer identified. The specialist referral rate following DARE was 5% (95% CI:3–8). Recruitment rates were significantly associated with the clinic setting (sexual health centre 78%, general practice 13%, hospital 14%, p=0.002) and specialty (sexual health physician 67%, general practitioner 20%, infectious disease physician 14%, p=0.031). Conclusion: Annual DARE to detect anal cancer in HIV-positive MSM was acceptable for patients, with minimal side effects. Strategies to increase HIV physician’s patient recruitment would be needed if DARE were to be implemented in anal cancer screening. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://purl.org/au-research/grants/nhmrc/APP1081175Test; http://purl.org/au-research/grants/nhmrc/APP1071269Test; http://hdl.handle.net/1959.4/unsworks_41511Test; https://doi.org/10.1177/0969141315604658Test |
| DOI: | 10.1177/0969141315604658 |
| الإتاحة: | https://doi.org/10.1177/0969141315604658Test http://hdl.handle.net/1959.4/unsworks_41511Test |
| حقوق: | metadata only access ; http://purl.org/coar/access_right/c_14cbTest ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.E3636D85 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0969141315604658 |
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