التفاصيل البيبلوغرافية
| العنوان: |
Models in biology: lessons from modeling regulation of the eukaryotic cell cycle |
| المؤلفون: |
Tyson, John, Novák, Béla |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2015 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Mathematical models, Mitosis-promoting factor, Cell cycle checkpoints, Regulated kinases, Regulated phosphatases, Regulated proteolysis |
| الوصف: |
In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms with many kinetic parameters. We describe how the mature models made surprising and informative predictions about the control system that were later confirmed experimentally. Along the way, we comment on the ‘parameter estimation problem’ and conclude with an appeal for a greater role for mathematical models in molecular cell biology. |
| نوع الوثيقة: |
review |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1741-7007/13/46Test |
| الإتاحة: |
http://www.biomedcentral.com/1741-7007/13/46Test |
| حقوق: |
Copyright 2015 Tyson and Novák. |
| رقم الانضمام: |
edsbas.E35D104C |
| قاعدة البيانات: |
BASE |
