دورية أكاديمية
Determination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases.
| العنوان: | Determination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases. |
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| المؤلفون: | Nguyen, Yann, Yelnik, Cécile, Morel, Nathalie, Paule, Romain, Stammler, Romain, Plaçais, Léo, Sacré, Karim, Godeau, Bertrand, Maillard, Hélène, Launay, David, Morell-Dubois, Sandrine, Dupré, Anastasia, Lefevre, Guillaume, Devloo, Cécile, Dufrost, Virginie, Benhamou, Ygal, Levesque, Hervé, Leroux, Gaëlle, Piette, Jean-Charles, Mouthon, Luc, Hachulla, Eric, Lambert, Marc, Le Guern, Véronique, Costedoat-Chalumeau, Nathalie |
| المساهمون: | Université de Lille, Inserm, CHU Lille, Centre for Research in Epidemiology and Statistics, Institute for Translational Research in Inflammation - U 1286 INFINITE (Ex-Liric), Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France CeRAINO, Centre de référence des maladies auto-immunes systémiques rares d'Île-de-France / National Reference Center for Rare Systemic Autoimmune Diseases, Hôpital Foch Suresnes, Service de médecine interne et centre de référence des maladies rares CHU Cochin, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), AP-HP - Hôpital Bichat - Claude Bernard Paris, Hôpital Henri Mondor, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Défaillance Cardiovasculaire Aiguë et Chronique DCAC, Endothélium, valvulopathies et insuffisance cardiaque EnVI, Université de Rouen Normandie UNIROUEN, CHU Pitié-Salpêtrière AP-HP |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | APS, cluster analysis, SLE |
| الوصف: | Objective APS is a heterogeneous disease with different phenotypes. Using an unsupervised hierarchical cluster analysis, we aimed to determine distinct homogeneous phenotypes among APS patients. Methods We performed an observational, retrospective study of APS patients enrolled in the French multicentre ‘APS and SLE’ registry who met the Sydney classification criteria. The clustering process involved an unsupervised multiple correspondence analysis followed by a hierarchical ascendant clustering analysis; it used 27 variables selected to cover a broad range of APS clinical and laboratory manifestations. Results These analyses included 509 patients, mainly women (77.8%). Mean (s.d.) age at APS diagnosis was 36.2 (14.6) years, and mean follow-up since diagnosis 10.3 (8.5) years. This hierarchical classification cluster analysis yielded four homogeneous groups of patients: cluster 1, mostly with venous thromboembolism without any associated autoimmune disease; cluster 2, older, lowest proportion of women, history of arterial events, and/or with migraines, arterial hypertension, diabetes mellitus, or dyslipidaemia; cluster 3, younger, highest proportion of women, associated SLE or other autoimmune diseases, and a history of venous thromboembolism or pregnancy morbidity; and cluster 4, mainly with a history of catastrophic antiphospholipid syndrome, aPL-associated nephropathy, and pregnancy morbidity, with frequent triple positivity and more deaths (16.7%). Conclusions Our study applied an unsupervised clustering method to distinguish four homogeneous APS patient subgroups that were predominantly venous; arterial; associated with SLE or another autoimmune disease; and arterial microthrombotic. Heterogeneous pathophysiological mechanisms may explain these findings. ; 62 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Rheumatology; Rheumatology (Oxford); http://hdl.handle.net/20.500.12210/100725Test |
| الإتاحة: | https://doi.org/20.500.12210/100725Test https://hdl.handle.net/20.500.12210/100725Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.E347AAEF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |