دورية أكاديمية
Albumin-based cancer therapeutics for intraperitoneal drug delivery : a review
| العنوان: | Albumin-based cancer therapeutics for intraperitoneal drug delivery : a review |
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| المؤلفون: | Van de Sande, Leen, Cosyns, Sarah, Willaert, Wouter, Ceelen, Wim |
| المصدر: | DRUG DELIVERY ; ISSN: 1071-7544 ; ISSN: 1521-0464 |
| سنة النشر: | 2020 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Pharmaceutical Science, General Medicine, Albumin, intraperitoneal delivery, peritoneal metastasis, chemotherapy, peritoneum |
| الوصف: | Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding sites, which are able to bind and transport numerous endogenous and exogenous compounds. The development of albumin-bound drugs is gaining increased importance in the targeted delivery of cancer therapy. Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal metastasis (PM). PM is characterized by the presence of widespread metastatic tumor nodules on the peritoneum, mostly originating from gastro-intestinal or gynaecological cancers. Albumin as a carrier for chemotherapy holds considerable promise for IP delivery in patients with PM. Data from recent (pre)clinical trials suggest that IP albumin-bound chemotherapy may result in superior efficacy in the treatment of PM compared to standard chemotherapy formulations. Here, we review the evidence on albumin-bound chemotherapy with a focus on IP administration and its efficacy in PM. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8639715Test; http://hdl.handle.net/1854/LU-8639715Test; http://dx.doi.org/10.1080/10717544.2019.1704945Test; https://biblio.ugent.be/publication/8639715/file/8639716Test |
| DOI: | 10.1080/10717544.2019.1704945 |
| الإتاحة: | https://doi.org/10.1080/10717544.2019.1704945Test https://biblio.ugent.be/publication/8639715Test http://hdl.handle.net/1854/LU-8639715Test https://biblio.ugent.be/publication/8639715/file/8639716Test |
| حقوق: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E3461B4B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/10717544.2019.1704945 |
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