التفاصيل البيبلوغرافية
| العنوان: |
Houttuynia cordata Targets the Beginning Stage of Herpes Simplex Virus Infection |
| المؤلفون: |
Hung, Pei-Yun, Ho, Bing-Ching, Lee, Szu-Yuan, Chang, Sui-Yuan, Kao, Chuan-Liang, Lee, Shoei-Sheng, Lee, Chun-Nan, 何炳慶, 李君男, 高全良, 李水盛, 張淑媛 |
| المساهمون: |
臺大醫院-檢驗醫學部, 臺大醫學院, 臺大醫學院-醫學檢驗暨生物技術學系暨研究所, 臺大醫學院-藥學系暨研究所, Hung, Pei-Yun, Ho, Bing-Ching, Lee, Szu-Yuan, Chang, Sui-Yuan, Kao, Chuan-Liang, Lee, Shoei-Sheng, Lee, Chun-Nan, 何炳慶, 李君男, 高全良, 李水盛, 張淑媛 |
| سنة النشر: |
2015 |
| المجموعة: |
National Taiwan University Institutional Repository (NTUR) |
| الوقت: |
154 |
| الوصف: |
Herpes simplex virus (HSV), a common latent virus in humans, causes certain severe diseases. Extensive use of acyclovir (ACV) results in the development of drug-resistant HSV strains, hence, there is an urgent need to develop new drugs to treat HSV infection. Houttuynia cordata (H. cordata), a natural herbal medicine, has been reported to exhibit anti-HSV effects which is partly NF-kappa B-dependent. However, the molecular mechanisms by which H. cordata inhibits HSV infection are not elucidated thoroughly. Here, we report that H. cordata water extracts (HCWEs) inhibit the infection of HSV-1, HSV-2, and acyclovir-resistant HSV-1 mainly via blocking viral binding and penetration in the beginning of infection. HCWEs also suppress HSV replication. Furthermore, HCWEs attenuate the first-wave of NF-kappa B activation, which is essential for viral gene expressions. Further analysis of six compounds in HCWEs revealed that quercetin and isoquercitrin inhibit NF-kappa B activation and additionally, quercetin also has an inhibitory effect on viral entry. These results indicate that HCWEs can inhibit HSV infection through multiple mechanisms and could be a potential lead for development of new drugs for treating HSV. ; 藥學系暨研究所 ; 醫學院 ; 期刊論文 |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| العلاقة: |
PLoS One, 10(2); http://ntur.lib.ntu.edu.tw/handle/246246/280721Test |
| DOI: |
10.1371/journal.pone.0115475 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0115475Test
http://ntur.lib.ntu.edu.tw/handle/246246/280721Test |
| رقم الانضمام: |
edsbas.E2F27A51 |
| قاعدة البيانات: |
BASE |
