دورية أكاديمية
The thrombotic risk in Cushing’s syndrome—questions, answers, and the algorithm to consider in its assessment: part I—thrombotic risk not related to surgery
| العنوان: | The thrombotic risk in Cushing’s syndrome—questions, answers, and the algorithm to consider in its assessment: part I—thrombotic risk not related to surgery |
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| المؤلفون: | Bryk-Wiązania, Agata Hanna, Minasyan, Mari, Świątkowska-Stodulska, Renata, Undas, Anetta, Hubalewska-Dydejczyk, Alicja, Webb, Susan M., Valassi, Elena, Gilis-Januszewska, Aleksandra |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2024 |
| المجموعة: | UIC Open Access Archive (Universitat Internacional de Catalunya) |
| مصطلحات موضوعية: | Síndrome de Cushing, Síndrome de l'hormona adrenocorticotròpica ectòpica, Tromboembolisme venós, Risc trombòtic, Tromboprofilaxi, Síndrome de hormona adrenocorticotrópica ectópica, Tromboembolismo venoso, Riesgo trombótico, Tromboprofilaxis, Cushing's syndrome, Ectopic adrenocorticotropic hormone syndrome, Venous thromboembolism, Thrombotic risk, Thromboprophylaxis |
| الوقت: | 61 |
| الوصف: | Introduction: Recently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing’s syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients. Methods: The four relevant topics and questions on thrombotic risk in CS were identified. The current guidelines on prevention and diagnosis of venous thromboembolism (VTE) were reviewed for the answers. An algorithm to consider in the assessment of the thrombotic risk in patients with CS was proposed. Results: To address both generic and CS-specific risk factors for VTE, the algorithm includes the stepwise approach consisting of Padua Score, urine free cortisol, and CS-VTE score, with no indication for routine thrombophilia testing in the prediction of an index VTE episode. Having confirmed VTE, selected patients require thrombophilia testing to aid the duration of anticoagulant treatment. The separate part of the algorithm is devoted to patients with ectopic adrenocorticotropic hormone syndrome in whom exclusion of VTE precedes introducing routine thromboprophylaxis to prevent VTE. The cancer-related VTE also prompts thromboprophylaxis, with the possible vessel invasion. The algorithm presents a unifactorial and multifactorial approach to exclude high-bleeding risks and safely introduce thromboprophylaxis with low-molecular-weight heparin. Summary: Our article is the first to present an algorithm to consider in the thrombotic risk assessment among patients with Cushing’s syndrome as a starting point for a broader discussion in the environment. A plethora of factors affect the VTE risk in patients with CS, but no studies have conclusively evaluated the best thromboprophylaxis strategy so far. Future studies are needed to set standards of care. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-2392 |
| العلاقة: | Frontiers in Endocrinology; 15; Bryk-Wiązania, Agata Hanna; Minasyan, Mari; Świątkowska-Stodulska, Renata [et al.]. The thrombotic risk in Cushing’s syndrome—questions, answers, and the algorithm to consider in its assessment: part I—thrombotic risk not related to surgery. Frontiers in Endocrinology, 2024, 15, 1350010. Disponible en: . Fecha de acceso: 5 abr. 2024. DOI:10.3389/fendo.2024.1350010; http://hdl.handle.net/20.500.12328/4187Test; https://dx.doi.org/10.3389/fendo.2024.1350010Test |
| DOI: | 10.3389/fendo.2024.1350010 |
| الإتاحة: | https://doi.org/20.500.12328/4187Test https://doi.org/10.3389/fendo.2024.1350010Test https://hdl.handle.net/20.500.12328/4187Test |
| حقوق: | © 2024 Bryk-Wiązania, Minasyan, Świątkowska-Stodulska, Undas, Hubalewska-Dydejczyk, Webb, Valassi and Gilis-Januszewska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E2D9148B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16642392 |
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| DOI: | 10.3389/fendo.2024.1350010 |