التفاصيل البيبلوغرافية
| العنوان: |
ORIGINAL ARTICLE Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity |
| المؤلفون: |
Adeline Bertola, Vanessa Deveaux, Stéphanie Bonnafous, Déborah Rousseau, Rodolphe Anty, Abdelilah Wakkach, Moncef Dahman, Joan Tordjman, Karine Clément, Siobhán E. Mcquaid, Keith N. Frayn, Pierre-michel Huet, Jean Gugenheim, Sophie Lotersztajn, Yannick Le March, Albert Tran |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/64/c3/Diabetes_2009_Jan_58(1)_125-133.tar.gz |
| المجموعة: |
CiteSeerX |
| الوصف: |
OBJECTIVE—Osteopontin (OPN) plays an important role in the development of insulin resistance and liver complications in dietary murine models. We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis. RESEARCH DESIGN AND METHODS—OPN and CD44 expressions were studied in 52 morbidly obese patients and in mice. Cellular studies were performed in HepG2 cells. RESULTS—Hepatic OPN and CD44 expressions were strongly correlated with liver steatosis and insulin resistance in obese patients and mice. This increased OPN expression could be due to the accumulation of triglycerides, since fat loading in HepG2 promotes OPN expression. In contrast, OPN expression in adipose tissue (AT) was enhanced independently of insulin resistance and hepatic steatosis in obese patients. The elevated OPN |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.3111Test |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.E2CB86C1 |
| قاعدة البيانات: |
BASE |
