رسالة جامعية
Phenotypic drug resistance investigation of various clinical HIV-1 genotypes ; Fenotypische karakterisatie van drug resistentie in verschillende klinische HIV-1 genotypes
| العنوان: | Phenotypic drug resistance investigation of various clinical HIV-1 genotypes ; Fenotypische karakterisatie van drug resistentie in verschillende klinische HIV-1 genotypes |
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| المؤلفون: | Megens, Sarah |
| المساهمون: | Van Laethem, Kristel, U0035492, Vandamme, Anne-Mieke, U0004051, Balzarini, Jan, U0005099 |
| سنة النشر: | 2015 |
| المجموعة: | KU Leuven: Lirias |
| الوصف: | Since the mid-nineties, the repertoire of antiv iral drugs for the treatment of human immunodefici ency virus type 1 (HIV-1) has diversified substant ially enabling the prescription of highly active a ntiviral therapy, even in patients who have failed multiple antiretroviral regimens. Despite th e potency of current antiviral drugs, therapy fail ures do occur. Viral replication in the prese nce of ART results into the generation and se lection of resistance mutations. If prolonged viro logical failure occurs, multiple resistance m utations can accumulate affecting more drugs withi n the prescribed regimen, as well as other drugs d ue to cross-resistance within the same drug class. Timely therapeutic interventions are ne eded in order to safeguard the options f or subsequent drug regimens and the long-term surv ival chances of the patient. HIV-1 drug resis tance tests are valuable tools for composing potent regimens but these tests are challenged by the high viral genetic variability. In Europe , genotypic drug resistance testing is the preferr ed and recommended method above phenotypic testing . However, the interpretation of genotypic dr ug resistance tests can be so complex that special ized expertise is needed. In order to refine¨ and improve genotypic drug resistance interpretati on systems, they need to be continuously updated w ith information on (interactions between) new ¨mutations. Before newly detected mutations are in cluded, their impact on in vitro dru g susceptibility and replication needs to be¨ investigated, as well as their impact on ¨the in vivo virological response. Up unt il ten years ago, basic and clinical HIV-1 researc h was mainly performed on HIV-1 subtype B, wh ich predominated in resource-rich settings. Insigh ts into the potency of antiviral drugs and regimen s as well as into the emergence of drug resistance ¨in non-B subtypes, was lacking. This triggered re search in this field, which was reviewed in chapte r 1. In the subsequent research sections, we contributed to a better ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | English |
| العلاقة: | https://lirias.kuleuven.be/handle/123456789/491400Test; https://lirias.kuleuven.be/bitstream/123456789/491400/1//Megens_thesis_final.pdfTest |
| الإتاحة: | https://lirias.kuleuven.be/handle/123456789/491400Test https://lirias.kuleuven.be/bitstream/123456789/491400/1//Megens_thesis_final.pdfTest |
| رقم الانضمام: | edsbas.E25B2AC8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |