دورية أكاديمية
Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
| العنوان: | Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV) |
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| المؤلفون: | Carramiñana A, Ferrando C, Unzueta MC, Navarro R, Suárez-Sipmann F, Tusman G, Garutti I, Soro M, Pozo N, Librero J, Gallego L, Ramasco F, Rabanal JM, Rodriguez A, Sastre J, Martinez J, Coves S, García P, Aguirre-Puig, Yepes J, Lluch A, López-Herrera D21, Leal S, Vives M, Bellas S, Socorro T, Trespalacios R, Salazar CJ, Mugarra A, Cinnella G, Spadaro S, Futier E30, Ferrer L31, Cabrera M32, Ribeiro H33, Celestino C, Kucur, Cervantes O, Morocho D, Delphy D, Ramos, Villar J, Belda J, iPROVE-OLV Network. |
| المساهمون: | Carramiñana, A, Ferrando, C, Unzueta, Mc, Navarro, R, Suárez-Sipmann, F, Tusman, G, Garutti, I, Soro, M, Pozo, N, Librero, J, Gallego, L, Ramasco, F, Rabanal, Jm, Rodriguez, A, Sastre, J, Martinez, J, Coves, S, García, P, Aguirre-Puig, Yepes, J, Lluch, A, López-Herrera, D21, Leal, S, Vives, M, Bellas, S, Socorro, T, Trespalacios, R, Salazar, Cj, Mugarra, A, Cinnella, G, Spadaro, S, Futier, E30, Ferrer, L31, Cabrera, M32, Ribeiro, H33, Celestino, C, Kucur, Cervantes, O, Morocho, D, Delphy, D, Ramos, Villar, J, Belda, J, iPROVE-OLV, Network. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | mechanical ventilation, one-lung ventilation, positive end-expiratory pressure, postoperative pulmonary complications, recruitment maneuvers |
| الوصف: | Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30928294; info:eu-repo/semantics/altIdentifier/wos/WOS:000483007700024; volume:33; issue:9; firstpage:2492; lastpage:2502; numberofpages:11; journal:JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA; http://hdl.handle.net/11392/2404274Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85063373855; https://www.sciencedirect.com/science/article/pii/S1053077019300928Test |
| DOI: | 10.1053/j.jvca.2019.01.056 |
| الإتاحة: | https://doi.org/10.1053/j.jvca.2019.01.056Test http://hdl.handle.net/11392/2404274Test https://www.sciencedirect.com/science/article/pii/S1053077019300928Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E25646DE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1053/j.jvca.2019.01.056 |
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