دورية أكاديمية
Hazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells
| العنوان: | Hazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells |
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| المؤلفون: | Carlin, Michela, Kaur, Jasreen, Ciobanu, Dinu Zinovie, Song, Zhengmei, Olsson, Magnus, Totu, Tiberiu, Gupta, Govind, Peng, Guotao, González, Viviana Jehová, Janica, Iwona, Pozo, Victor Fuster, Chortarea, Savvina, Buljan, Marija, Buerki-Thurnherr, Tina, Rio Castillo, Antonio Esau del, Thorat, Sanjay B., Bonaccorso, Francesco, Tubaro, Aurelia, Vazquez, Ester, Prato, Maurizio |
| المصدر: | Journal of Hazardous Materials, 473 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | 2D materials, Cytotoxicity, Composites, Omics, Life cycle perspective |
| الوصف: | Hexagonal boron nitride (hBN) is an emerging two-dimensional material attracting considerable attention in the industrial sector given its innovative physicochemical properties. Potential risks are associated mainly with occupational exposure where inhalation and skin contact are the most relevant exposure routes for workers. Here we aimed at characterizing the effects induced by composites of thermoplastic polyurethane (TPU) and hBN, using immortalized HaCaT skin keratinocytes and BEAS-2B bronchial epithelial cells. The composite was abraded using a Taber® rotary abraser and abraded TPU and TPU-hBN were also subjected to photo-Fenton-mediated degradation mimicking potential weathering across the product life cycle. Cells were exposed to the materials for 24 h (acute exposure) or twice per week for 4 weeks (chronic exposure) and evaluated with respect to material internalization, cytotoxicity, and proinflammatory cytokine secretion. Additionally, comprehensive mass spectrometry-based proteomics and metabolomics (secretomics) analyses were performed. Overall, despite evidence of cellular uptake of the material, no significant cellular and/or protein expression profiles alterations were observed after acute or chronic exposure of HaCaT or BEAS-2B cells, identifying only few pro-inflammatory proteins. Similar results were obtained for the degraded materials. These results support the determination of hazard profiles associated with cutaneous and pulmonary hBN-reinforced polymer composites exposure. ; ISSN:0304-3894 ; ISSN:1873-3336 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/grantAgreement/EC/H2020/881603; http://hdl.handle.net/20.500.11850/675769Test |
| DOI: | 10.3929/ethz-b-000675769 |
| الإتاحة: | https://doi.org/20.500.11850/67576910.3929/ethz-b-00067576910.1016/j.jhazmat.2024.134686Test https://hdl.handle.net/20.500.11850/675769Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Creative Commons Attribution 4.0 International |
| رقم الانضمام: | edsbas.E24511E8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000675769 |
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