التفاصيل البيبلوغرافية
| العنوان: |
Varicella-Zoster Virus Modulates NF-κB Recruitment on Selected Cellular Promoters |
| المؤلفون: |
El Mjiyad, Nadia, Bontems, Sébastien, Gloire, Geoffrey, Horion, Julie, Vandevenne, Patricia, Dejardin, Emmanuel, Piette, Jacques, Sadzot-Delvaux, Catherine |
| المصدر: |
Journal of Virology ; volume 81, issue 23, page 13092-13104 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: |
American Society for Microbiology |
| سنة النشر: |
2007 |
| الوصف: |
Intercellular adhesion molecule 1 (ICAM-1) expression is down-regulated in the center of cutaneous varicella lesions despite the expression of proinflammatory cytokines such as gamma interferon and tumor necrosis factor alpha (TNF-α). To study the molecular basis of this down-regulation, the ICAM-1 induction of TNF-α was analyzed in varicella-zoster virus (VZV)-infected melanoma cells (MeWo), leading to the following observations: (i) VZV inhibits the stimulation of icam-1 mRNA synthesis; (ii) despite VZV-induced nuclear translocation of p65, p52, and c-Rel, p50 does not translocate in response to TNF-α; (iii) the nuclear p65 present in VZV-infected cells is no longer associated with p50 and is unable to bind the proximal NF-κB site of the icam-1 promoter, despite an increased acetylation and accessibility of the promoter in response to TNF-α; and (iv) VZV induces the nuclear accumulation of the NF-κB inhibitor p100. VZV also inhibits icam-1 stimulation of TNF-α by strongly reducing NF-κB nuclear translocation in MRC5 fibroblasts. Taken together, these data show that VZV interferes with several aspects of the immune response by inhibiting NF-κB binding and the expression of target genes. Targeting NF-κB activation, which plays a central role in innate and adaptive immune responses, leads to obvious advantages for the virus, particularly in melanocytes, which are a site of viral replication in the skin. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1128/jvi.01378-07 |
| DOI: |
10.1128/JVI.01378-07 |
| الإتاحة: |
https://doi.org/10.1128/jvi.01378-07Test |
| حقوق: |
https://journals.asm.org/non-commercial-tdm-licenseTest |
| رقم الانضمام: |
edsbas.E1D7DAA9 |
| قاعدة البيانات: |
BASE |
