دورية أكاديمية
Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis
| العنوان: | Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis |
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| المؤلفون: | Giles, F J, Mauro, M J, Hong, F, Ortmann, C-E, McNeill, C, Woodman, R C, Hochhaus, A, le Coutre, P D, Saglio, G |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2013 |
| المجموعة: | National University of Ireland (NUI), Galway: ARAN |
| مصطلحات موضوعية: | chronic myeloid leukemia, nilotinib, imatinib, ponatinib, tyrosine kinase inhibitor, peripheral arterial occlusive disease, diagnosed chronic-phase, risk-factors, matrix accumulation, follow-up, prevalence, mesylate, atherosclerosis, cardiotoxicity, management, sunitinib |
| الوصف: | Peripheral arterial occlusive disease (PAOD) occurs in patients with chronic phase chronic myeloid leukemia (CML-CP) treated with tyrosine kinase inhibitors (TKIs). The risk of developing PAOD on TKI therapy is unknown and causality has not been established. Patients with CML-CP from three randomized phase III studies (IRIS, TOPS and ENESTnd) were divided into three cohorts: no TKI (cohort 1; n = 533), nilotinib (cohort 2; n = 556) and imatinib (cohort 3; n = 1301). Patients with atherosclerotic risk factors were not excluded. Data were queried for terms indicative of PAOD. Overall, 3, 7 and 2 patients in cohorts 1, 2 and 3, respectively, had PAOD; 11/12 patients had baseline PAOD risk factors. Compared with that of cohort 1, exposure-adjusted risks of PAOD for cohorts 2 and 3 were 0.9 (95% CI, 0.2-3.3) and 0.1 (95% CI, 0.0-0.5), respectively. Multivariate logistic regression revealed that nilotinib had no impact on PAOD rates compared with no TKI, whereas imatinib had decreased rates of PAOD compared with no TKI. Nilotinib was associated with higher rates of PAOD versus imatinib. Baseline assessments, preferably within clinical studies, of PAOD and associated risk factors should occur when initiating TKI therapy in CML; patients should receive monitoring and treatment according to the standard of care for these comorbidities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Leukemia; Giles, F J; Mauro, M J; Hong, F; Ortmann, C-E; McNeill, C; Woodman, R C; Hochhaus, A; le Coutre, P D; Saglio, G (2013). Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis. Leukemia 27 (6), 1310-1315; 0887-6924,1476-5551; http://hdl.handle.net/10379/11638Test |
| DOI: | 10.1038/leu.2013.69 |
| الإتاحة: | https://doi.org/10.1038/leu.2013.69Test http://hdl.handle.net/10379/11638Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 Ireland ; https://creativecommons.org/licenses/by-nc-nd/3.0/ieTest/ |
| رقم الانضمام: | edsbas.E1B61096 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/leu.2013.69 |
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