دورية أكاديمية
Effect of Ouabain and Alterations in Potassium Concentration on Relaxation Induced by Sodium Nitroprusside
| العنوان: | Effect of Ouabain and Alterations in Potassium Concentration on Relaxation Induced by Sodium Nitroprusside |
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| المؤلفون: | Rapoport, Robert M., Murad, Ferid |
| المصدر: | Journal of Vascular Research ; volume 20, issue 5, page 255-264 ; ISSN 1018-1172 1423-0135 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 1983 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, Physiology |
| الوصف: | Relaxation of the rat thoracic aorta induced by sodium nitroprusside, 8-bromo-cyclic GMP and cyclic nucleotide phosphodiesterase inhibitor M & B 22,948 was inhibited by exposure to K + -free solution and ouabain in a concentration-dependent manner. Relaxation occurring with the change in potassium concentration in media from 1 to 2 to 10 mM was increased by sodium nitroprusside, 8-bromo-cyclic GMP and M & B 22,948. Thus, agents and procedures known to decrease and increase the activity of the Na + , K + -pump, and presumably alter the membrane potential, inhibited and enhanced relaxation, respectively. Exposure to 1 mM K + solution increased the relaxation to low concentrations of sodium nitroprusside, but had no effect on relaxation induced by 8-bromo-cyclic GMP or M & B 22,948. Thus, another procedure which inhibits the Na + , K + -pump enhanced the effect of low concentrations of sodium nitroprusside on relaxation. Ouabain had no effect on sodium nitroprusside-induced accumulation of cyclic GMP. These results suggest that sodium nitroprusside may induce relaxation through cyclic GMP formation, effects on the Na + , K + -pump and/or hyper-polarization of the smooth muscle cell membrane. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000158478 |
| الإتاحة: | https://doi.org/10.1159/000158478Test https://www.karger.com/Article/Pdf/158478Test |
| حقوق: | https://www.karger.com/Services/SiteLicensesTest ; https://www.karger.com/Services/SiteLicensesTest |
| رقم الانضمام: | edsbas.E194BB7E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000158478 |
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