دورية أكاديمية
Manufacturing methods, properties, and potential applications in bone tissue regeneration of hydroxyapatite-chitosan biocomposites: A review
| العنوان: | Manufacturing methods, properties, and potential applications in bone tissue regeneration of hydroxyapatite-chitosan biocomposites: A review |
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| المؤلفون: | Ait Said, H., Mabroum, H., Lahcini, M., Oudadesse, H., Barroug, A., Ben Youcef, H., Noukrati, H. |
| المساهمون: | Université Mohammed VI Polytechnique Ben Guerir (UM6P), Université Cadi Ayyad Marrakech (UCA), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), OCP Innovation, Centre National pour la Recherche Scientifique et Technique, CNRST, Ministère de l'Enseignement Supérieur, de la Recherche Scientifique et de la Formation des Cadres, MESRSFC, Fondation OCP, (MAT-BAR-01/2017) |
| المصدر: | ISSN: 0141-8130 ; International Journal of Biological Macromolecules ; https://hal.science/hal-04164344Test ; International Journal of Biological Macromolecules, 2023, 243, pp.125150. ⟨10.1016/j.ijbiomac.2023.125150⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | Biocomposite, Biomedical, Chitosan, Drug delivery, Hydroxyapatite, [CHIM]Chemical Sciences, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Hydroxyapatite (HA) and chitosan (CS) biopolymer are the major materials investigated for biomedical purposes. Both of these components play an important role in the orthopedic field as bone substitutes or drug release systems. Used separately, the hydroxyapatite is quite fragile, while CS mechanical strength is very weak. Therefore, a combination of HA and CS polymer is used, which provides excellent mechanical performance with high biocompatibility and biomimetic capacity. Moreover, the porous structure and reactivity of the hydroxyapatite-chitosan (HA-CS) composite allow their application not only as a bone repair but also as a drug delivery system providing controlled drug release directly to the bone site. These features make biomimetic HA-CS composite a subject of interest for many researchers. Through this review, we provide the important recent achievements in the development of HA-CS composites, focusing on manufacturing techniques, conventional and novel three-dimensional bioprinting technology, and physicochemical and biological properties. The drug delivery properties and the most relevant biomedical applications of the HA-CS composite scaffolds are also presented. Finally, alternative approaches are proposed to develop HA composites with the aim to improve their physicochemical, mechanical, and biological properties. © 2023 Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37285882; hal-04164344; https://hal.science/hal-04164344Test; https://hal.science/hal-04164344/documentTest; https://hal.science/hal-04164344/file/Said%20et%20al.%20-%202023%20-%20Manufacturing%20methods,%20properties,%20and%20potential%20a.pdfTest; PUBMED: 37285882 |
| DOI: | 10.1016/j.ijbiomac.2023.125150 |
| الإتاحة: | https://doi.org/10.1016/j.ijbiomac.2023.125150Test https://hal.science/hal-04164344Test https://hal.science/hal-04164344/documentTest https://hal.science/hal-04164344/file/Said%20et%20al.%20-%202023%20-%20Manufacturing%20methods,%20properties,%20and%20potential%20a.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E164D4F6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijbiomac.2023.125150 |
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