دورية أكاديمية
Effect of different asthma treatments on risk of cold-related exacerbations
| العنوان: | Effect of different asthma treatments on risk of cold-related exacerbations |
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| المؤلفون: | Reddel, HK, Jenkins, C, Quirce, S, Sears, MR, Bateman, ED, O'Byrne, PM, Humbert, M, Buhl, R, Harrison, T, Brusselle, Guy, Thorén, A, Sjöbring, U, Peterson, S, Östlund, O, Eriksson, GS |
| المصدر: | EUROPEAN RESPIRATORY JOURNAL ; ISSN: 0903-1936 |
| سنة النشر: | 2011 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Asthma, drug therapy, exacerbations, respiratory tract infections, AIRWAY EPITHELIAL-CELLS, BETA(2)-ADRENOCEPTOR AGONISTS, INHALED CORTICOSTEROIDS, COMBINATION THERAPY, RELIEVER THERAPY, CONTROLLED-TRIAL, RHINOVIRUS, BUDESONIDE, BUDESONIDE/FORMOTEROL, MAINTENANCE |
| الوصف: | Common colds often trigger asthma exacerbations. The present study compared cold-related severe exacerbations during budesonide/formoterol maintenance and reliever therapy, and different regimens of maintenance inhaled corticosteroids (ICS), with or without long-acting beta(2)-agonists (LABA), and with as-needed short-acting beta(2)-agonists (SABA) or LABA. Reported colds and severe exacerbations (defined by oral corticosteroid use and/or hospitalisation/emergency room visit) were assessed for 12,507 patients during 6-12 months of double-blind treatment. Exacerbations occurring <= 14 days after onset of reported colds were analysed by a Poisson model. The incidence of colds was similar across treatments. Asthma symptoms and reliever use increased during colds. Budesonide/formoterol maintenance and reliever therapy reduced severe cold-related exacerbations by 36% versus pooled comparators plus SABA (rate ratio (RR) 0.64; p=0.002), and for individual treatment comparisons, by 52% versus the same maintenance dose of ICS/LABA (RR 0.48; p < 0.001); there were nonsignificant reductions versus higher maintenance doses of ICS or ICS/LABA (RR 0.83 and 0.72, respectively). As-needed LABA did not reduce cold-related exacerbations versus as-needed SABA (RR 0.96). Severe cold-related exacerbations were reduced by budesonide/formoterol maintenance and reliever therapy compared with ICS with or without LABA and with as-needed SABA. Subanalyses suggested the importance of the ICS component in reducing cold-related exacerbations. Future studies should document the cause of exacerbations, in order to allow identification of different treatment effects. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/2025940Test; http://hdl.handle.net/1854/LU-2025940Test; http://dx.doi.org/10.1183/09031936.00186510Test; https://biblio.ugent.be/publication/2025940/file/2026218Test |
| DOI: | 10.1183/09031936.00186510 |
| الإتاحة: | https://doi.org/10.1183/09031936.00186510Test https://biblio.ugent.be/publication/2025940Test http://hdl.handle.net/1854/LU-2025940Test https://biblio.ugent.be/publication/2025940/file/2026218Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E15A1CD0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1183/09031936.00186510 |
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