دورية أكاديمية
N‐Acetyl‐l‐cysteine abolishes the bromoethylamine‐induced choline incorporation into renal papillary tissue
| العنوان: | N‐Acetyl‐l‐cysteine abolishes the bromoethylamine‐induced choline incorporation into renal papillary tissue |
|---|---|
| المؤلفون: | Thielemann, L. E., Rodrigo Salinas, Ramón, Oberhauser, E. W., Rosenblut, G., Videla Cabrera, Luis |
| المصدر: | Journal of Biochemical Toxicology |
| سنة النشر: | 1995 |
| المجموعة: | Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: | Bromoethylamine, Choline Phospholipids, N‐Acetyl‐L‐cysteine, Renal Papillary Necrosis |
| الوصف: | The role of regenerative processes in the protective effect of N‐acetyl‐L‐cysteine (NAC) against bromoethylamine‐induced renal papillary necrosis was assessed in rats given bromoethylamine (BEA) (1.2 mmol/kg), N‐acetylcysteine (6 mmol/kg), or N‐acetylcysteine plus BEA. Renal papillary slices were dissected after 15 hours of treatment, and 14C‐choline incorporation into total phospholipid, lysophosphatidylcholine, sphingomyelin, and phosphatidylcholine was measured. Bromoethylamine elicited an increase in the incorporation of 14C‐choline into choline‐containing phospholipid, an effect that was abolished when N‐acetylcysteine was administered prior to bromoethylamine. These studies indicate that the defensive mechanism of N‐acetylcysteine against bromoethylamine‐induced renal papillary necrosis is not related to regenerative processes and that N‐acetylcysteine abolishes the bromoethylamine‐induced choline incorporation into papillary phospholipid. © 1996 John Wiley & Sons, Inc. Copyright |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 15227146 08872082 |
| العلاقة: | Journal of Biochemical Toxicology, Volumen 10, Issue 5, 2018, Pages 251-257; http://repositorio.uchile.cl/handle/2250/161406Test |
| DOI: | 10.1002/jbt.2570100505 |
| الإتاحة: | https://doi.org/10.1002/jbt.2570100505Test http://repositorio.uchile.cl/handle/2250/161406Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/clTest/ |
| رقم الانضمام: | edsbas.E11F6ECC |
| قاعدة البيانات: | BASE |
| تدمد: | 15227146 08872082 |
|---|---|
| DOI: | 10.1002/jbt.2570100505 |