دورية أكاديمية
Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019–2022 prospective study with cluster and network analysis
| العنوان: | Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019–2022 prospective study with cluster and network analysis |
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| المؤلفون: | Pesqué, David, Borrego Hernando, Leopoldo, Zaragoza-Ninet, Violeta, Sanz-Sánchez, Tatiana, Miquel-Miquel, Francisco Javier, González-Pérez, Ricardo, Silvestre, Juan Francisco, Córdoba-Guijarro, Susana, Carrascosa, José Manuel, Gatica-Ortega, María Elena, Ruiz-González, Inmaculada, Mercader-García, Pedro, Tous-Romero, Fátima, Ortiz de Frutos, Francisco Javier, Serra-Baldrich, Esther, Pastor-Nieto, María Antonia, Rodríguez-Serna, Mercedes, Sánchez Pérez, Javier, Sánchez-Gilo, Araceli, Melé-Ninot, Gemma, Sánchez-Pedreño Guillén, Paloma, Pujol, Ramon Maria, Giménez-Arnau, Ana María |
| المساهمون: | orcid:0000-0002-5821-9780, orcid:0000-0002-0199-2756, NO DATA, orcid:0000-0003-4266-0771, orcid:0000-0002-8203-5834, orcid:0000-0002-3904-3396, orcid:0000-0001-8382-5419, orcid:0000-0003-4941-6405, orcid:0000-0003-0365-0634, orcid:0000-0001-5434-7753, 57220890156, 7004025265, 24337144700, 6506960206, 6506759329, 55909809000, 58850883800, 35569505100, 35548523800, 57194638206, 6603455998, 57216168318, 57188587516, 6602083415, 6701845879, 15128697400, 7004163814, 7006076733, 35782206200, 55991704800, 6602337891, 57188660875, 24068420100, BU-MED |
| المصدر: | Journal of the European Academy of Dermatology and Venereology[ISSN 0926-9959], (Febrero 2024) |
| سنة النشر: | 2024 |
| المجموعة: | Universidad de Las Palmas de Gran Canaria: Acceda |
| مصطلحات موضوعية: | 32 Ciencias médicas, 320106 Dermatología |
| الوصف: | Background: There is still limited clinical-practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS). Objectives: To determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation. Methods: Prospective multicentric study (January 2019–December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC). Clinical and patch test data of polysensitized and oligosensitized patients were compared, and risk factors of PS were investigated with logistic multivariate regression. Unsupervised hierarchical clustering and network analysis were used to study allergen aggregation in PS. Results: A total of 10,176 patients were analysed. PS was found in 844 (8.3%). Current relevance was significantly higher in polysensitized patients (p < 0.01). Risk factors for PS were atopic dermatitis (OR: 1.58, 95% CI: 1.24–2.02), age (≥60 years vs. ≤24 years, OR: 1.75, 95% CI: 1.25–2.44) and some special locations (legs vs. face OR: 1.54, 95% CI: 1.05–2.25, hands vs. face OR: 1.46, 95% CI:1.15–1.85, arms vs. face OR: 1.49, 95% CI:1.01–2.20, trunk vs. face OR: 1.40, 95% CI:1.06–1.85). Cluster and network analyses revealed specific-allergen clusters and significant associations, including allergens belonging to metals group, fragrances and botanicals group, topical drugs group, rubber allergens and biocides. Conclusions: This study confirms that PS is structured by discernible patterns of specific-allergen clusters and reinforces significant allergen associations in PS. Cross-reactivity and/or concomitant sensitization could explain the formation of allergen clusters in PS. ; 10 ; 1,51 ; 9,2 ; Q1 ; Q1 ; SCIE ; 11,0 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0926-9959 1468-3083 |
| العلاقة: | Journal of the European Academy of Dermatology and Venereology; Scopus; http://hdl.handle.net/10553/129530Test; 85186563596; Sí |
| DOI: | 10.1111/jdv.19934 |
| الإتاحة: | https://doi.org/10.1111/jdv.19934Test http://hdl.handle.net/10553/129530Test |
| رقم الانضمام: | edsbas.E0E7F348 |
| قاعدة البيانات: | BASE |
| تدمد: | 09269959 14683083 |
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| DOI: | 10.1111/jdv.19934 |