دورية أكاديمية
The Role of PEMFs on Bone Healing: An In Vitro Study
| العنوان: | The Role of PEMFs on Bone Healing: An In Vitro Study |
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| المؤلفون: | Caliogna, Laura, Bina, Valentina, Brancato, Alice Maria, Gastaldi, Giulia, Annunziata, Salvatore, Mosconi, Mario, Grassi, Federico, Benazzo, Francesco, Pasta, Gianluigi |
| المساهمون: | Caliogna, Laura, Bina, Valentina, Brancato, Alice Maria, Gastaldi, Giulia, Annunziata, Salvatore, Mosconi, Mario, Grassi, Federico, Benazzo, Francesco, Pasta, Gianluigi |
| سنة النشر: | 2022 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | bone regeneration, fracture healing, fracture repair, human adipose mesenchymal stem cells (hASCs), human osteoblasts (hOBs), osteogenic differentiation, pulsed electromagnetic fields (PEMFs), Human, Osteogenesi, Cell Differentiation, Osteoblast, Electromagnetic Field, Mesenchymal Stem Cells |
| الوصف: | Bone responses to pulsed electromagnetic fields (PEMFs) have been extensively studied by using devices that expose bone cells to PEMFs to stimulate extracellular matrix (ECM) synthesis for bone and cartilage repair. The aim of this work was to highlight in which bone healing phase PEMFs exert their action. Specifically, we evaluated the effects of PEMFs both on human adipose mesenchymal stem cells (hASCs) and on primary human osteoblasts (hOBs) by testing gene and protein expression of early bone markers (on hASCs) and the synthesis of late bone-specific proteins (on hOBs) as markers of bone remodeling. Our results indicate that PEMFs seem to exert their action on bone formation, acting on osteogenic precursors (hASCs) and inducing the commitment towards the differentiation pathways, unlike mature and terminally differentiated cells (hOBs), which are known to resist homeostasis perturbation more and seem to be much less responsive than mesenchymal stem cells. Understanding the role of PEMFs on bone regenerative processes provides important details for their clinical application. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36430775; volume:23; issue:22; firstpage:14298; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11571/1467594Test |
| DOI: | 10.3390/ijms232214298 |
| الإتاحة: | https://doi.org/10.3390/ijms232214298Test https://hdl.handle.net/11571/1467594Test |
| رقم الانضمام: | edsbas.E0B1789D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms232214298 |
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