دورية أكاديمية
The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease
| العنوان: | The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease |
|---|---|
| المؤلفون: | Geraldes, R, Juryńczyk, M, Dos Passos, GR, Pichler, A, Chung, K, Hagens, M, Ruggieri, S, Auger, C, Sastre-Garriga, J, Enzinger, C, Chard, D, Barkhof, F, Gasperini, C, Rovira, A, DeLuca, G, Palace, J, MAGNIMS study group, . |
| المصدر: | Multiple Sclerosis Journal (2020) (In press). |
| سنة النشر: | 2020 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Multiple sclerosis, cerebral small vessel disease, differential diagnosis, imaging |
| الوصف: | BACKGROUND: Differentiating multiple sclerosis (MS) from vascular risk factor (VRF)-small vessel disease (SVD) can be challenging. OBJECTIVE AND METHODS: In order to determine whether or not pontine lesion location is a useful discriminator of MS and VRF-SVD, we classified pontine lesions on brain magnetic resonance imaging (MRI) as central or peripheral in 93 MS cases without VRF, 108 MS patients with VRF and 43 non-MS cases with VRF. RESULTS: MS without VRF were more likely to have peripheral pons lesions (31.2%, 29/93) than non-MS with VRF (0%, 0/43) (Exp(B) = 29.8; 95% confidence interval (CI) = (1.98, 448.3); p = 0.014) but there were no significant differences regarding central pons lesions between MS without VRF (5.4%, 5/93) and non-MS with VRF patients (16.3%, 7/43) (Exp(B) = 0.89; 95% CI = (0.2, 3.94); p = 0.87). The presence of peripheral pons lesions discriminated between MS and VRF-SVD with 100% (95% CI = (91.8, 100)) specificity. The proportion of peripheral pons lesions in MS with VRF (30.5%, 33/108) was similar to that seen in MS without VRF (31.2%, 29/93, p = 0.99). Central lesions occurred in similar frequency in MS with VRF (8.3%, 9/108) and non-MS with VRF (16.3%, 7/43, p = 0.15). CONCLUSION: Peripheral pons lesion location is a good discriminator of MS from vascular lesions. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10109508/3/Barkhof_The%20role%20of%20pontine%20lesion%20location%20in%20differentiating%20multiple%20sclerosis%20from%20vascular%20risk%20factor-related%20small%20vessel%20disease_AAM.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10109508Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10109508/3/Barkhof_The%20role%20of%20pontine%20lesion%20location%20in%20differentiating%20multiple%20sclerosis%20from%20vascular%20risk%20factor-related%20small%20vessel%20disease_AAM.pdfTest https://discovery.ucl.ac.uk/id/eprint/10109508Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.E099615D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |