دورية أكاديمية
Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes
| العنوان: | Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes |
|---|---|
| المؤلفون: | Carla Iacobini, Martina Vitale, Jonida Haxhi, Carlo Pesce, Giuseppe Pugliese, Stefano Menini |
| المساهمون: | Iacobini, Carla, Vitale, Martina, Haxhi, Jonida, Pesce, Carlo, Pugliese, Giuseppe, Menini, Stefano |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | advanced glycation end product, atherosclerosi, diabetic kidney disease, inflammation, methylglyoxal, prolyl hydroxylase domain protein, reactive oxygen specie, sirtuin-1, sodium glucose co-transporter 2 inhibitor, Warburg effect |
| الوصف: | Oxidative stress and hypoxia-inducible factors (HIFs) have been implicated in the pathogenesis of diabetic cardiovascular and renal diseases. Reactive oxygen species (ROS) mediate physiological and pathophysiological processes, being involved in the modulation of cell signaling, differentiation, and survival, but also in cyto- and genotoxic damage. As master regulators of glycolytic metabolism and oxygen homeostasis, HIFs have been largely studied for their role in cell survival in hypoxic conditions. However, in addition to hypoxia, other stimuli can regulate HIFs stability and transcriptional activity, even in normoxic conditions. Among these, a regulatory role of ROS and their byproducts on HIFs, particularly the HIF-1 alpha isoform, has received growing attention in recent years. On the other hand, HIF-1 alpha and HIF-2 alpha exert mutually antagonistic effects on oxidative damage. In diabetes, redox-mediated HIF-1 alpha deregulation contributes to the onset and progression of cardiovascular and renal complications, and recent findings suggest that deranged HIF signaling induced by hyperglycemia and other cellular stressors associated with metabolic disorders may cause mitochondrial dysfunction, oxidative stress, and inflammation. Understanding the mechanisms of mutual regulation between HIFs and redox factors and the specific contribution of the two main isoforms of HIF-alpha is fundamental to identify new therapeutic targets for vascular complications of diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36358555; info:eu-repo/semantics/altIdentifier/wos/WOS:000880684400001; volume:11; issue:11; firstpage:1; lastpage:23; numberofpages:23; journal:ANTIOXIDANTS; https://hdl.handle.net/11573/1659621Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85141760945 |
| DOI: | 10.3390/antiox11112183 |
| الإتاحة: | https://doi.org/10.3390/antiox11112183Test https://hdl.handle.net/11573/1659621Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E081CE61 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/antiox11112183 |
|---|