التفاصيل البيبلوغرافية
| العنوان: |
Modulatory effects of bortezomib on host immune cell functions |
| المؤلفون: |
Pellom, Samuel Troy, Dudimah, Duafalia Fred, Thounaojam, Menaka Chanu, Sayers, Thomas Joseph, Shanker, Anil |
| المصدر: |
Immunotherapy ; volume 7, issue 9, page 1011-1022 ; ISSN 1750-743X 1750-7448 |
| بيانات النشر: |
Informa UK Limited |
| سنة النشر: |
2015 |
| الوصف: |
Bortezomib is an inhibitor of the ubiquitin-proteasome proteolytic pathway responsible for intracellular protein turnover. Cellular proteins controlled by this pathway represent a diverse group of potential therapeutic targets, particularly in cancer cells, which exploit this proteasomal pathway to promote their growth and diminish apoptosis. Along with inhibiting the proteasome and thus sensitizing tumor cells to apoptosis, bortezomib may also have multiple effects on the host immune responses. This review summarizes the effects that bortezomib may play on immune cell subsets in various disease states in modifying lymphocyte receptors, ligands, the expression of various cytokines and chemokines and their downstream signaling. We also propose steps that can be taken to refine combinatorial strategies that include bortezomib to improve current immunotherapeutic approaches. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.2217/imt.15.66 |
| الإتاحة: |
https://doi.org/10.2217/imt.15.66Test |
| رقم الانضمام: |
edsbas.E070C10C |
| قاعدة البيانات: |
BASE |
