التفاصيل البيبلوغرافية
| العنوان: |
Eosinophilic Airway Diseases: From Pathophysiological Mechanisms to Clinical Practice |
| المؤلفون: |
Mauro Mormile, Ilaria Mormile, Salvatore Fuschillo, Francesca Wanda Rossi, Laura Lamagna, Pasquale Ambrosino, Amato de Paulis, Mauro Maniscalco |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7254 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
asthma, biomarkers, chronic obstructive pulmonary disease, chronic rhinosinusitis with nasal polyps, eosinophils, disability, rehabilitation, outcome |
| جغرافية الموضوع: |
agris |
| الوصف: |
Eosinophils play a key role in airway inflammation in many diseases, such as allergic and non-allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. In these chronic disabling conditions, eosinophils contribute to tissue damage, repair, remodeling, and disease persistence through the production a variety of mediators. With the introduction of biological drugs for the treatment of these respiratory diseases, the classification of patients based on clinical characteristics (phenotype) and pathobiological mechanisms (endotype) has become mandatory. This need is particularly evident in severe asthma, where, despite the great scientific efforts to understand the immunological pathways underlying clinical phenotypes, the identification of specific biomarkers defining endotypes or predicting pharmacological response remains unsatisfied. In addition, a significant heterogeneity also exists among patients with other airway diseases. In this review, we describe some of the immunological differences in eosinophilic airway inflammation associated with severe asthma and other airway diseases and how these factors might influence the clinical presentation, with the aim of clarifying when eosinophils play a key pathogenic role and, therefore, represent the preferred therapeutic target. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Immunology; https://dx.doi.org/10.3390/ijms24087254Test |
| DOI: |
10.3390/ijms24087254 |
| الإتاحة: |
https://doi.org/10.3390/ijms24087254Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.E02B1325 |
| قاعدة البيانات: |
BASE |
