دورية أكاديمية
Effects of continuous and interrupted orthodontic force on interleukin-1棺 and prostaglandin E2 production in gingival crevicular fluid
| العنوان: | Effects of continuous and interrupted orthodontic force on interleukin-1棺 and prostaglandin E2 production in gingival crevicular fluid |
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| المساهمون: | Kee-Joon Lee, Young-Chel Park, Yun-Jung Yoo, Seong-Ho Choi, Hyung-Seog Yu, Park, Young Chel, Yoo, Yun Jung, Yu, Hyung Seog, Lee, Kee Joon, Choi, Seung Ho |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adolescent, Adult, Analysis of Variance, Bicuspid/surgery, Cuspid/physiopathology, Dental Alloys, Dinoprostone/analysis, Dinoprostone/metabolism, Feedback, Female, Follow-Up Studies, Gingival Crevicular Fluid/chemistry, Humans, Interleukin-1/analysis, Interleukin-1/metabolism, Male, Nickel, Orthodontic Wires, Serial Extraction, Stress, Mechanical, Time Factors, Titanium, Tooth Movement Techniques/instrumentation, Tooth Movement Techniques/methods, Up-Regulation |
| الوصف: | The purpose of this study was to evaluate the effects of a light continuous force and an interrupted force with weekly reactivation on interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)); possible interactions between these 2 potent mediators of the bone resorption process were assessed in vivo. Ten healthy young adults (mean age 20.6 years, 2 men, 8 women) with 4 premolars extracted were assessed. In each subject, 1 maxillary canine (E1) received continuous force with a nickel-titanium coil spring. The opposite canine (E2) received an interrupted force with a screw-attached retractor; the force was reactivated weekly by 2 turns of the screw. An antagonistic canine was used as a control. Gingival crevicular fluid was collected from the distal side of each tooth, 10 times in 3 weeks, and IL-1beta and PGE(2) levels were measured. For E1, the IL-1beta level showed a significant elevation at 24 hours and then decreased and maintained an insignificant but high mean concentration, compared with the control site. The PGE(2) level showed a significant elevation at 24 hours and then decreased. For E2, a significant elevation of IL-1beta level was observed at 24 hours and a greater significant elevation at 24 hours after the first reactivation, compared with the control sites. The PGE(2) level increased significantly at 24 hours and remained high for 1 week. The synergistic up-regulation of PGE(2) by appliance reactivation and secreted IL-1beta was not evident with either type of force after 1 week. Both experimental sites showed significant tooth movement compared with the control sites at 3 weeks; however, there was no significant difference between the 2 experimental sites. A well-controlled mechanical stress with timely reactivation can effectively upregulate IL-1beta secretion, but there might be limitations in increasing the mediator levels, because of the feedback mechanisms in vivo. In addition, the analysis of crevicular fluid is a useful method for assessing cellular response to orthodontic force in ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 168~177 |
| اللغة: | unknown |
| تدمد: | 0889-5406 1097-6752 |
| العلاقة: | AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS; J00098; OAK-2004-01574; https://ir.ymlib.yonsei.ac.kr/handle/22282913/111676Test; http://www.sciencedirect.com/science/article/pii/S0889540603008515Test; T200402807; AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, Vol.125(2) : 168-177, 2004 |
| DOI: | 10.1016/j.ajodo.2003.03.006 |
| الإتاحة: | https://doi.org/10.1016/j.ajodo.2003.03.006Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/111676Test http://www.sciencedirect.com/science/article/pii/S0889540603008515Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; not free |
| رقم الانضمام: | edsbas.DFE62CBD |
| قاعدة البيانات: | BASE |
| تدمد: | 08895406 10976752 |
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| DOI: | 10.1016/j.ajodo.2003.03.006 |