دورية أكاديمية
Live imaging of neurogenesis in the adult mouse hippocampus
| العنوان: | Live imaging of neurogenesis in the adult mouse hippocampus |
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| المؤلفون: | Pilz, Gregor-Alexander, Bottes, Sara, Betizeau, Marion, Jörg, David J, Carta, Stefano, Simons, Benjamin D, Helmchen, Fritjof, Jessberger, Sebastian |
| المصدر: | Pilz, Gregor-Alexander; Bottes, Sara; Betizeau, Marion; Jörg, David J; Carta, Stefano; Simons, Benjamin D; Helmchen, Fritjof; Jessberger, Sebastian (2018). Live imaging of neurogenesis in the adult mouse hippocampus. Science, 359(6376):658-662. |
| بيانات النشر: | American Association for the Advancement of Science |
| سنة النشر: | 2018 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Brain Research Institute, 570 Life sciences, biology, 610 Medicine & health |
| الوصف: | Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1) promoter undergo limited rounds of symmetric and asymmetric divisions, eliciting a burst of neurogenic activity, after which they are lost. Further, our data reveal unexpected asymmetric divisions of nonradial glia-like NSPCs. Cell fates of Ascl1-labeled lineages suggest a developmental-like program involving a sequential transition from a proliferative to a neurogenic phase. By providing a comprehensive description of lineage relationships, from dividing NSPCs to newborn neurons integrating into the hippocampal circuitry, our data offer insight into how NSPCs support life-long hippocampal neurogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0036-8075 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/165603/1/658.full.pdfTest; info:pmid/29439238; urn:issn:0036-8075 |
| DOI: | 10.5167/uzh-165603 |
| DOI: | 10.1126/science.aao5056 |
| الإتاحة: | https://doi.org/10.5167/uzh-16560310.1126/science.aao5056Test https://www.zora.uzh.ch/id/eprint/165603Test/ https://www.zora.uzh.ch/id/eprint/165603/1/658.full.pdfTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.DFC39C8E |
| قاعدة البيانات: | BASE |
| تدمد: | 00368075 |
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| DOI: | 10.5167/uzh-165603 |