دورية أكاديمية
The effect of genetic polymorphisms on treatment duration following premolar extraction
| العنوان: | The effect of genetic polymorphisms on treatment duration following premolar extraction |
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| المساهمون: | Jiyon Yu, Yoon Jeong Choi, Sung-Hwan Choi, Han-Sung Jung, Ji Hyun Lee, Jung-Yul Cha |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adolescent, Adult, Bicuspid / surgery, Case-Control Studies, Duration of Therapy, Female, Gene Expression, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Membrane Proteins / genetics, Middle Aged, Orthodontics / methods, Osteopontin / genetics, Polymorphism, Single Nucleotide, RANK Ligand / genetics, Receptors, Purinergic P2X7 / genetics, Retrospective Studies, Transcriptome, Treatment Outcome, Wnt3A Protein / genetics |
| الوصف: | To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | SCIENTIFIC REPORTS; J02646; OAK-2021-07493; https://ir.ymlib.yonsei.ac.kr/handle/22282913/186828Test; T202104708; SCIENTIFIC REPORTS, Vol.11(1) : 15942, 2021-08 |
| DOI: | 10.1038/s41598-021-94979-8 |
| الإتاحة: | https://doi.org/10.1038/s41598-021-94979-8Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/186828Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.DF70823D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-94979-8 |