التفاصيل البيبلوغرافية
| العنوان: |
Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study |
| المؤلفون: |
METASTROKE Collaboration of the International Stroke Genetics Consortium |
| المساهمون: |
Circulatory Health, CDL Onderzoek Pasterkamp, dLAB Afdelingen, CMM Groep Kaaij |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Brain Ischemia/epidemiology, Causality, Cholesterol, LDL/blood, Coronary Disease/epidemiology, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Hyperlipidemias/drug therapy, Hypolipidemic Agents/therapeutic use, Mendelian Randomization Analysis, Stroke/epidemiology, Clinical Neurology, Research Support, Non-U.S. Gov't, Journal Article |
| الوصف: |
To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach.MethodsWe undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate the causal effects of LDL-C for IS and IS subtypes (based on 12,389 IS cases from METASTROKE) and for CHD (based on 60,801 cases from CARDIoGRAMplusC4D). We then assessed the effects of LDL-C on IS and CHD for heterogeneity.ResultsA 1 mmol/L higher genetically determined LDL-C was associated with a 50% higher risk of CHD (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.32-1.68, p = 1.1 × 10 -8). By contrast, the causal effect of LDL-C was much weaker for IS (OR 1.12, 95% CI 0.96-1.30, p = 0.14; p for heterogeneity = 2.6 × 10 -3) and, in particular, for cardioembolic stroke (OR 1.06, 95% CI 0.84-1.33, p = 0.64; p for heterogeneity = 8.6 × 10 -3) when compared with that for CHD.ConclusionsIn contrast with the consistent effects of LDL-C-lowering therapies on IS and CHD, genetic variants that confer lifelong LDL-C differences show a weaker effect on IS than on CHD. The relevance of etiologically distinct IS subtypes may contribute to the differences observed. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
image/pdf |
| اللغة: |
English |
| تدمد: |
0028-3878 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/381205Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/381205Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.DF6E509F |
| قاعدة البيانات: |
BASE |
