دورية أكاديمية
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
| العنوان: | Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity |
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| المؤلفون: | Galderisi, Alfonso, Tricò, Domenico, Lat, Jessica O, Samuels, Stephanie L, Weiss, Ram, Van Name, Michelle, Pierpont, Bridget, Santoro, Nicola, Caprio, Sonia |
| المساهمون: | Galderisi, Alfonso, Tricò, Domenico, Lat, Jessica O, Samuels, Stephanie L, Weiss, Ram, Van Name, Michelle, Pierpont, Bridget, Santoro, Nicola, Caprio, Sonia |
| سنة النشر: | 2023 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Diabete, Endocrinology, Glucose metabolism, Metabolism, Obesity |
| الوصف: | In youth with obesity, the gut hormone potentiation of insulin secretion - the incretin effect - is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on beta cell function and insulin sensitivity. Youths with obesity and 2-h glucose≥120mg/dL underwent a 3-h OGTT and an isoglycemic intravenous glucose infusion to quantify the incretin effect. After 2 years, 30/39 participants had a repeated OGTT and were stratified into three tertiles according to the baseline incretin effect. Thirty participants completed the baseline and follow-up tests. The high-incretin effect group demonstrated a longitudinal increase in beta cell function (DIMM) (p=0.034), with greater insulin sensitivity at follow-up (p=0.034) and stable insulin secretion (φtotal) (p=0.077). A lower incretin effect at baseline was associated with a higher 1-h and 2-h glucose at follow-up (r = -0.558, p=0.001 and r = -0.533, p=0.004). The high-incretin effect group displayed a greater increase of GLP-17-36 than the moderate- and low-incretin group at baseline (p=0.008 and p=0.029), while such a difference did not persist after 2 years. Glucagon suppression was reduced at follow-up in those with low-baseline incretin respect to the high-incretin group (p=0.049). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37847560; info:eu-repo/semantics/altIdentifier/wos/WOS:001111341800001; journal:JCI INSIGHT; https://hdl.handle.net/11577/3498742Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85178383636 |
| DOI: | 10.1172/jci.insight.165709 |
| الإتاحة: | https://doi.org/10.1172/jci.insight.165709Test https://hdl.handle.net/11577/3498742Test |
| رقم الانضمام: | edsbas.DF0B039A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/jci.insight.165709 |
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